Temporal precision of molecular events with regulation and feedback.,Physical Review E

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Temporal precision of molecular events with regulation and feedback.
Physical Review E ( IF 2.2 ) Pub Date : 2020-06-26 , DOI: 10.1103/physreve.101.062420
Shivam Gupta ₁ , Sean Fancher _{1,

2} , Hendrik C Korswagen ₃ , Andrew Mugler ₁

Affiliation

Cellular behaviors such as migration, division, and differentiation rely on precise timing, and yet the molecular events that govern these behaviors are highly stochastic. We investigate regulatory strategies that decrease the timing noise of molecular events. Autoregulatory feedback increases noise. Yet we find that in the presence of regulation by a second species, autoregulatory feedback decreases noise. To explain this finding, we develop a method to calculate the optimal regulation function that minimizes the timing noise. The method reveals that the combination of feedback and regulation minimizes noise by maximizing the number of molecular events that must happen in sequence before a threshold is crossed. We compute the optimal timing precision for all two-node networks with regulation and feedback, derive a generic lower bound on timing noise, and discuss our results in the context of neuroblast migration during Caenorhabditis elegans development.

中文翻译：

具有调节和反馈的分子事件的时间精度。

细胞行为（例如迁移，分裂和分化）依赖于精确的时间，但是控制这些行为的分子事件是高度随机的。我们研究减少分子事件的时间噪声的调控策略。自动调节反馈会增加噪声。但是我们发现，在第二种物种进行调节的情况下，自调节反馈会降低噪声。为了解释这一发现，我们开发了一种计算最佳调节函数的方法，该函数可最大程度地减小时序噪声。该方法揭示了反馈和调节的结合，通过最大化在超过阈值之前必须依序发生的分子事件的数量，将噪声最小化。我们通过调节和反馈为所有两节点网络计算最佳定时精度，秀丽隐杆线虫的发展。

更新日期：2020-06-26

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