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Elastomeric polyamide biomaterials with stereochemically tuneable mechanical properties and shape memory.
Nature Communications ( IF 14.7 ) Pub Date : 2020-06-26 , DOI: 10.1038/s41467-020-16945-8
Joshua C Worch 1 , Andrew C Weems 1 , Jiayi Yu 2 , Maria C Arno 1 , Thomas R Wilks 1 , Robert T R Huckstepp 3 , Rachel K O'Reilly 1 , Matthew L Becker 4 , Andrew P Dove 1
Affiliation  

Biocompatible polymers are widely used in tissue engineering and biomedical device applications. However, few biomaterials are suitable for use as long-term implants and these examples usually possess limited property scope, can be difficult to process, and are non-responsive to external stimuli. Here, we report a class of easily processable polyamides with stereocontrolled mechanical properties and high-fidelity shape memory behaviour. We synthesise these materials using the efficient nucleophilic thiol-yne reaction between a dipropiolamide and dithiol to yield an α,β − unsaturated carbonyl moiety along the polymer backbone. By rationally exploiting reaction conditions, the alkene stereochemistry is modulated between 35–82% cis content and the stereochemistry dictates the bulk material properties such as tensile strength, modulus, and glass transition. Further access to materials possessing a broader range of thermal and mechanical properties is accomplished by polymerising a variety of commercially available dithiols with the dipropiolamide monomer.



中文翻译:


具有立体化学可调机械性能和形状记忆的弹性聚酰胺生物材料。



生物相容性聚合物广泛应用于组织工程和生物医学设备应用。然而,很少有生物材料适合用作长期植入物,并且这些例子通常具有有限的性能范围,可能难以加工,并且对外部刺激无反应。在这里,我们报告了一类易于加工的聚酰胺,具有立体控制的机械性能和高保真形状记忆行为。我们利用二丙醇酰胺和二硫醇之间的有效亲核硫醇-炔反应来合成这些材料,以沿着聚合物主链产生α,β-不饱和羰基部分。通过合理利用反应条件,烯烃立体化学可调节在 35-82%顺式含量之间,并且立体化学决定了本体材料的性能,例如拉伸强度、模量和玻璃化转变。通过将各种市售二硫醇与二丙醇酰胺单体聚合,可以进一步获得具有更广泛的热性能和机械性能的材料。

更新日期:2020-06-26
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