Soft Printable Electrode Coating for Neural Interfaces,ACS Applied Bio Materials

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Soft Printable Electrode Coating for Neural Interfaces
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-06-26 , DOI: 10.1021/acsabm.0c00401
Michael Shur ₁ , Florian Fallegger ₁ , Elvira Pirondini _{2,

3} , Adrien Roux _{4,

5} , Arnaud Bichat _{1,

3,

6} , Quentin Barraud _{3,

6} , Grégoire Courtine _{3,

6} , Stéphanie P Lacour ₁

Affiliation

The mechanical mismatch between implantable interfaces and neural tissues may be reduced by employing soft polymeric materials. Here, we report on a simple strategy to prepare and pattern a soft electrode coating of neural interfacing devices based on a screen-printable conducting hydrogel. The coating formulation, based on polyacrylamide and poly(3,4-ethylenedioxythiophene) polystyrene sulfonate, is suitable to additive manufacturing and exhibits excellent adhesion to polydimethylsiloxane, an elastomer commonly used as a substrate in soft neural interfaces. The soft conductive coating displays a tunable elastic modulus in the 10–100 kPa range and electrochemical properties on a par with stiff conductive inks while supporting good neural cell attachment and proliferation in vitro. Next, the soft printable hydrogel is integrated within a 4 × 4 microelectrode array for electrocorticography with 250 μm-diameter contacts. Acute recording of cortical local field potentials and electrochemical characterization preimplantation and postimplantation highlight the stability of the soft organic conductor. The overall robustness of the soft coating and its patterning method provide a promising route for a range of implantable bioelectronic applications.

中文翻译：

用于神经接口的软可印刷电极涂层

可植入界面和神经组织之间的机械失配可以通过采用软聚合物材料来减少。在这里，我们报告了一种简单的策略，用于制备和图案化基于可丝网印刷的导电水凝胶的神经接口装置的软电极涂层。该涂料配方基于聚丙烯酰胺和聚 (3,4-乙烯二氧噻吩) 聚苯乙烯磺酸盐，适用于增材制造，并且对聚二甲基硅氧烷具有出色的附着力，聚二甲基硅氧烷是一种弹性体，通常用作软神经界面的基材。软导电涂层在 10-100 kPa 范围内显示出可调的弹性模量和与硬质导电油墨相当的电化学性能，同时支持良好的神经细胞体外附着和增殖。下一个，可打印的软水凝胶集成在一个 4 × 4 微电极阵列中，用于皮层电描记术，具有 250 μm 直径的触点。皮质局部场电位的急性记录和植入前和植入后的电化学表征突出了软有机导体的稳定性。软涂层的整体稳健性及其图案化方法为一系列可植入生物电子应用提供了一条有希望的途径。

更新日期：2020-07-20

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