Abstract The antibacterial efficacy of hydrogen peroxide encapsulated in micelles (mH2O2) against biofilms was compared with that of hydrogen peroxide alone and of three commercially available aqueous biocides. The activity of mH2O2 on 24-h biofilms of reference strains of Staphylococcus spp. and Pseudomonas aeruginosa was tested in a static microtiter plate model. The biofilms were incubated with mH2O2 (17% v/v H2O2, 2% lactic acid, 0.3% phytoextract, H2O) and its individual ingredients and compared with three aqueous biocides at different concentrations and times of exposure. After 5-min exposure, 10% mH2O2 (corresponding to 1.7% v/v H2O2) achieved > 8 log10 reductions against all the test strains, while 1.7% H2O2 achieved a maximum of 1.5 log10 reduction. After 5-min exposure, none of the commercially available biocides tested showed themselves to be capable of completely eliminating the test strains embedded in biofilms. Hydrogen peroxide encapsulated in micelles demonstrated enhanced activity against planktonic cells and biofilms of Staphylococcus spp. and P. aeruginosa.

中文翻译：

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基于天然植物提取物的新型胶束配方可增强过氧化氢对葡萄球菌属生物膜的功效。和铜绿假单胞菌

摘要 将包裹在胶束 (mH2O2) 中的过氧化氢与单独的过氧化氢和三种市售水性杀菌剂的抗菌功效进行了比较。mH2O2 对葡萄球菌属参考菌株 24 小时生物膜的活性。和铜绿假单胞菌在静态微量滴定板模型中进行测试。将生物膜与 mH2O2（17% v/v H2O2、2% 乳酸、0.3% 植物提取物、H2O）及其各个成分一起孵育，并与不同浓度和暴露时间的三种水性杀菌剂进行比较。暴露 5 分钟后，10% mH2O2（对应于 1.7% v/v H2O2）对所有测试菌株实现了 > 8 log10 的减少，而 1.7% H2O2 实现了 1.5 log10 的最大减少。曝光 5 分钟后，测试的市售杀菌剂中没有一种表明它们能够完全消除嵌入生物膜中的测试菌株。包裹在胶束中的过氧化氢显示出对浮游细胞和葡萄球菌属生物膜的增强活性。和铜绿假单胞菌。