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Flexible recruitment of memory-based choice representations by the human medial frontal cortex
Science ( IF 41.845 ) Pub Date : 2020-06-26 , DOI: 10.1126/science.aba3313
Juri Minxha, Ralph Adolphs, Stefano Fusi, Adam N. Mamelak, Ueli Rutishauser

Decision-making in complex environments relies on flexibly using prior experience. This process depends on the medial frontal cortex (MFC) and the medial temporal lobe, but it remains unknown how these structures implement selective memory retrieval. We recorded single neurons in the MFC, amygdala, and hippocampus while human subjects switched between making recognition memory–based and categorization-based decisions. The MFC rapidly implemented changing task demands by using different subspaces of neural activity and by representing the currently relevant task goal. Choices requiring memory retrieval selectively engaged phase-locking of MFC neurons to amygdala and hippocampus field potentials, thereby enabling the routing of memories. These findings reveal a mechanism for flexibly and selectively engaging memory retrieval and show that memory-based choices are preferentially represented in the frontal cortex when required.
更新日期:2020-06-26

 

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