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Loading messenger RNAs onto ribosomes in human mitochondria: lessons learned from a bacterial toxin.
The FEBS Journal ( IF 5.5 ) Pub Date : 2020-06-25 , DOI: 10.1111/febs.15435
Lukasz S Borowski 1, 2 , Roman J Szczesny 1
Affiliation  

Mitochondria are peculiar organelles because their function depends on genetic information that is present in two genomes: nuclear and mitochondrial. The expression of mitochondrially encoded information requires dedicated machinery. Many efforts have been made to identify this machinery and describe its relevant mechanisms. Recently, Bruni et al. reported a cellular model that they established to investigate the pathway for loading messenger RNAs onto ribosomes in human mitochondria. Their study revealed a role for monosome formation in the stability of mitochondrial mRNAs. Comment on: https://doi.org/10.1111/febs.15342

中文翻译:

将信使RNA加载到人线粒体的核糖体上:从细菌毒素中学到的教训。

线粒体是特殊的细胞器,因为它们的功能取决于存在于两个基因组中的遗传信息:核基因组和线粒体。线粒体编码信息的表达需要专门的机器。已经做出了许多努力来识别这种机制并描述其相关机制。最近,Bruni等人。他们报道了他们建立的一种细胞模型,用于研究将信使RNA加载到人线粒体中核糖体的途径。他们的研究揭示了单核糖体形成在线粒体mRNA稳定性中的作用。评论:https://doi.org/10.1111/febs.15342
更新日期:2020-06-25
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