The shape memory polymers have attained huge attention as smart materials owing to their enormous benefits in the context of the common class of thermoplastics. In this study, novel thermal‐stimulus‐based hydroxyapatite (HA) reinforced polylactic acid (PLA) scaffolds have been developed through three‐dimensional (3D) printing technology. Initially, the effect of various processing parameters, such as the proportion of HA in PLA and infill density, and level of stimulating temperature, on tensile, flexural, and compression strength of the developed composite scaffolds have been studied to understand their effects, through statistically assisted single and multiobjective optimization techniques. The shape recovery factor of the prestrained composite scaffolds has been assessed by providing thermal‐stimulus. Finally, the biological performance of the developed scaffolds has been evaluated through in vitro cell culture and wettability analysis. The morphological study of the composite scaffolds, at different stages, has been performed for understanding the effect of processing parameters on the mechanical, shape recovery effect, and biological responses. Overall, the results of the study highlighted that the 3D printed scaffolds possessed nearly 95.77% shape memory effect along with desirable mechanical, in vitro biocompatibility, and hydrophilic morphology suitable to be a potential candidate of fabricating customized biomedical devices with activated shape recovery abilities.

中文翻译：

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基于三维印刷的热刺激聚乳酸-羟基磷灰石的形状记忆支架的表征

形状记忆聚合物由于在普通热塑性塑料类别中的巨大优势而作为智能材料受到了广泛关注。在这项研究中，已经通过三维（3D）打印技术开发了新型的基于热刺激的羟基磷灰石（HA）增强聚乳酸（PLA）支架。最初，已经研究了各种加工参数（例如PLA中HA的比例和填充密度以及刺激温度水平）对开发的复合支架的拉伸，挠曲和压缩强度的影响，以通过统计学方式了解其影响。辅助的单目标和多目标优化技术。通过提供热刺激评估了预应力复合支架的形状恢复因子。最后，体外细胞培养和润湿性分析。为了了解加工参数对机械，形状恢复效果和生物学响应的影响，已对复合支架进行了不同阶段的形态学研究。总体而言，研究结果强调了3D打印支架具有近95.77％的形状记忆效果以及理想的机械，体外生物相容性和亲水性形态，适合于制造具有激活的形状恢复能力的定制生物医学设备。