Design Rationale for Stimuli-Responsive, Semi-interpenetrating Polymer Network Hydrogels-A Quantitative Approach.,Macromolecular Rapid Communications

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Design Rationale for Stimuli-Responsive, Semi-interpenetrating Polymer Network Hydrogels-A Quantitative Approach.
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2020-06-26 , DOI: 10.1002/marc.202000199
Nupur Gupta ₁ , Yen Nan Liang ₁ , Jacob Song Kiat Lim ₂ , Xiao Hu _{1,

2}

Affiliation

Stimuli‐responsive semi‐interpenetrating polymer network (semi‐IPN) hydrogels form an important class of polymers for their tunable properties via molecular design. They are widely investigated for a diverse range of applications including drug delivery, sensors, actuators, and osmotic agents. However, in‐depth studies on some of the critical design principles affecting diffusion/leaching of linear polymer from semi‐IPN hydrogels are lacking. Herein, for the first time, by preparing a series of model semi‐IPN hydrogels based on thermally responsive poly (N‐isopropyl acrylamide) (PNIPAM) network and linear poly(sodium acrylate) (PSA), a systematic and quantitative study concerning linear polymer chain retention and swelling/deswelling kinetics is reported. The study shows that PSA retention is significantly affected not only by PSA molecular weight and concentration, but also by polymerization temperature, which could be linked to homogeneity and internal morphology of the hydrogel. Surprisingly, there is no obvious influence of crosslinking density of PNIPAM network toward PSA retention, while faster swelling and deswelling at higher crosslinking density are observed in terms of swelling rate constant and deswelling activation energy. These findings offer new insights on the factors affecting structural and physicochemical properties of such semi‐IPN hydrogels, which should in turn serve as a general guideline for materials design.

中文翻译：

刺激响应，半互穿聚合物网络水凝胶的设计原理-一种定量方法。

刺激响应的半互穿聚合物网络（semi-IPN）水凝胶通过分子设计可形成可调性，从而成为一类重要的聚合物。对它们的广泛应用进行了广泛的研究，包括药物输送，传感器，致动器和渗透剂。但是，缺乏对影响半IPN水凝胶中线性聚合物扩散/浸出的一些关键设计原理的深入研究。在这里，这是第一次，通过制备一系列基于热响应聚（N-异丙基丙烯酰胺（PNIPAM）网络和线性聚丙烯酸钠（PSA），报道了有关线性聚合物链保留和溶胀/溶胀动力学的系统和定量研究。研究表明，PSA的保留不仅受PSA分子量和浓度的影响，而且受聚合温度的影响，而聚合温度可能与水凝胶的均质性和内部形态有关。令人惊讶地，PNIPAM网络的交联密度对PSA保留没有明显的影响，而在溶胀速率常数和溶胀活化能方面，在较高的交联密度下观察到更快的溶胀和溶胀。这些发现为影响此类半IPN水凝胶的结构和物理化学性质的因素提供了新的见解，

更新日期：2020-06-26

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