Bacterial Sensing and Biofilm Monitoring for Infection Diagnostics.,Macromolecular Bioscience

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Bacterial Sensing and Biofilm Monitoring for Infection Diagnostics.
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-06-26 , DOI: 10.1002/mabi.202000129
Onur Parlak _{1,

2} , Agneta Richter-Dahlfors _{1,

2,

3}

Affiliation

Recent insights into the rapidly emerging field of bacterial sensing and biofilm monitoring for infection diagnostics are discussed as well as recent key developments and emerging technologies in the field. Electrochemical sensing of bacteria and bacterial biofilm via synthetic, natural, and engineered recognition, as well as direct redox‐sensing approaches via algorithm‐based optical sensing, and tailor‐made optotracing technology are discussed. These technologies are highlighted to answer the very critical question: “how can fast and accurate bacterial sensing and biofilm monitoring be achieved? Following on from that: “how can these different sensing concepts be translated for use in infection diagnostics? A central obstacle to this transformation is the absence of direct and fast analysis methods that provide high‐throughput results and bio‐interfaces that can control and regulate the means of communication between biological and electronic systems. Here, the overall progress made to date in building such translational efforts at the level of an individual bacterial cell to a bacterial community is discussed.

中文翻译：

用于感染诊断的细菌传感和生物膜监测。

讨论了对用于感染诊断的快速新兴的细菌传感和生物膜监测领域的最新见解，以及该领域的最新关键发展和新兴技术。讨论了通过合成、自然和工程识别对细菌和细菌生物膜的电化学传感，以及通过基于算法的光学传感和定制的光追踪技术的直接氧化还原传感方法。强调这些技术来回答非常关键的问题：“如何实现快速准确的细菌传感和生物膜监测？从那以后：“如何将这些不同的传感概念转化为用于感染诊断？这种转变的一个主要障碍是缺乏直接和快速的分析方法来提供高通量结果和可以控制和调节生物和电子系统之间通信方式的生物接口。在这里，讨论了迄今为止在单个细菌细胞到细菌群落的水平上建立这种转化工作的总体进展。

更新日期：2020-06-26

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