BACKGROUND Patients with a systemic right ventricle are prone to develop heart failure. Abnormal heart rate variability (HRV), a measure of autonomic dysfunction, is associated with morbidity and mortality in patients with left ventricular failure. The association between HRV and supraventricular arrhythmias (SVTs), which are associated with adverse events in this population, was assessed. METHODS 24-Hour Holter recordings of patients with a systemic right ventricle and healthy controls were analysed in a retrospective cohort study. HRV was calculated and compared between groups. Correlation coefficients were determined for HRV variables and clinical characteristics. The relation between HRV and SVTs was investigated with linear regression. RESULTS The patient group included 29 patients (69%) late after Mustard or Senning correction for transposition of the great arteries, and 13 patients with congenitally corrected transposition of the great arteries (31%). The control group included 38 subjects. HRV was significantly lower in patients compared with controls. In the patient group, lower SDANN (standard deviation of the average NN intervals calculated over 5-minute intervals) was independently associated with a higher number of supraventricular arrhythmias (95% CI -0.03 to -0.0004, p = 0.045). In exploratory correlation analysis, several HRV variables correlated with echocardiographic systemic right ventricular function (rho = 0.36, p = 0.02 for SDANN), and exercise capacity (rho = 0.39, p = 0.05 for SDANN). CONCLUSION In patients with a systemic right ventricle, HRV is lower compared with controls and (SDANN) is independently associated with supraventricular arrhythmias.

中文翻译：

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全身性右心室患者心率变异性降低与室上性快速性心律失常之间的关联

背景技术具有全身性右心室的患者容易发生心力衰竭。异常心率变异性 (HRV) 是一种衡量自主神经功能障碍的指标，与左心室衰竭患者的发病率和死亡率有关。评估了 HRV 与室上性心律失常 (SVT) 之间的关联，后者与该人群中的不良事件相关。方法 在一项回顾性队列研究中分析了全身性右心室患者和健康对照的 24 小时动态心电图记录。计算并比较组间 HRV。确定 HRV 变量和临床特征的相关系数。HRV和SVT之间的关系用线性回归研究。结果 患者组包括 29 例 (69%) 在 Mustard 或 Senning 矫正大动脉转位后晚期患者，13 名先天性大动脉转位矫正患者 (31%)。对照组包括38名受试者。与对照组相比，患者的 HRV 显着降低。在患者组中，较低的 SDANN（在 5 分钟间隔内计算的平均 NN 间隔的标准偏差）与较高数量的室上性心律失常独立相关（95% CI -0.03 至 -0.0004，p = 0.045）。在探索性相关分析中，几个 HRV 变量与超声心动图全身右心室功能（rho = 0.36，对于 SDANN p = 0.02）和运动能力（对于 SDANN，rho = 0.39，p = 0.05）相关。结论 在全身性右心室患者中，