The article presents a new normalization of flow-mediated dilation (FMD) in the radial artery, taking into account the parameter BSSR being equal to the ratio of the basal shear rate (BS) measured before the cuff inflation and post occlusive shear rate (SR). The in vivo usefulness of the new normalization algorithm was evaluated in two groups of patients. In group I, comprising 15 healthy volunteers, the normalized FMD/SR was (3.19 ± 1.4)•10^–4, while in group II, comprising 13 patients with stable coronary artery disease (CAD), it was (1.02 ± 0.76)•10^–4. We calculated almost 50% larger difference between the average values after normalizing FMD/BSSR. Specifically, the FMD/BSSR was equal to 28 ± 9.40 in group I and 6.01 ± 3.74 in group II. The prediction of CAD patients based on FMD/SR values had a sensitivity of 83.3% and a specificity of 84.6%, whereas the prediction of CAD patients based on the FMD/BSSR values revealed 100% sensitivity and specificity. These results confirm the usefulness of the novel normalization algorithm of the FMD in differentiation of normal patients from those with stable CAD.

本文介绍了桡动脉中血流介导扩张 (FMD) 的新标准化，考虑到参数 BSSR 等于在袖带充气前测量的基础剪切速率 (BS) 与闭塞后剪切速率 (SR) 之比）。在体内的新归一化算法的有用性在两组患者进行评价。在包含 15 名健康志愿者的 I 组中，归一化 FMD/SR 为 (3.19 ± 1.4)•10 ^–4，而在包含 13 名稳定型冠状动脉疾病 (CAD) 患者的 II 组中，归一化 FMD/SR为 (1.02 ± 0.76)• 10 ^–4. 我们计算出在标准化 FMD/BSSR 后平均值之间的差异将近 50%。具体来说，FMD/BSSR 在 I 组中等于 28 ± 9.40，在 II 组中等于 6.01 ± 3.74。根据 FMD/SR 值预测 CAD 患者的敏感性为 83.3%，特异性为 84.6%，而基于 FMD/BSSR 值预测 CAD 患者的敏感性和特异性为 100%。这些结果证实了新的 FMD 归一化算法在区分正常患者与稳定 CAD 患者中的有用性。