Visible light photocatalytic cascade cyclization reaction between glycine derivatives and β-ketoesters using Ir (ppy)₃ as a catalyst and dicumyl peroxide (DCP) as an oxidant was described. A series of N-aryl glycine esters proceeded the cyclization smoothly with β-ketoesters at room temperature, affording the desired 1,4-dihydropyridines (1,4-DHPs) in satisfactory yields. A possible mechanism for the cascade cyclization reaction by visible light photoredox catalysis was also proposed. This protocol not only provides an efficient and convenient approach to synthetize various 1,4-dihydropyridines, but also has potential utilities for the construction of bioactive molecules.

描述了使用Ir（ppy）₃作为催化剂和过氧化二枯基（DCP）作为氧化剂的甘氨酸衍生物与β-酮酸酯之间的可见光光催化级联环化反应。一系列N-芳基甘氨酸酯与β-酮酸酯在室温下顺利进行环化反应，以令人满意的产率提供所需的1,4-二氢吡啶（1,4-DHPs）。还提出了可见光氧化还原催化级联环化反应的可能机理。该协议不仅为合成各种1,4-二氢吡啶提供了一种高效便捷的方法，而且还具有潜在的实用性来构建生物活性分子。