2,3-Dialdehyde cellulose (DAC) was used as an efficient and low-toxicity crosslinker to prepare thin PVA/DAC hydrogel films designed for topical applications such as drug-loaded patches, wound dressings or cosmetic products. An optimization of hydrogel properties was achieved by the variation of two factors – the amount of crosslinker and the weight-average molecular weight (M_w) of the source PVA. The role of each factor to network parameters, mechanical, rheological and surface properties, hydrogel porosity and transdermal absorption is discussed. The best results were obtained for hydrogel films prepared using 0.25 wt% of DAC and PVA with M_w = 130 kDa, which had a high porosity and drug-loading capacity (high water content), mechanical properties allowing easy handling, best adherence to the skin from all tested samples and improved transdermal drug-delivery. Hydrogel films are biocompatible, show no cytotoxicity and have no negative impact on cell growth and morphology in their presence. Furthermore, hydrogels do not support cell migration and attachment to their surface, which should ensure easy removal of hydrogel patches even from wounded or damaged skin after use.

2,3-二醛纤维素（DAC）被用作一种高效且低毒的交联剂，用于制备PVA / DAC水凝胶薄膜，专门用于局部应用，例如载药的贴剂，伤口敷料或化妆品。通过改变两个因素（交联剂的量和源PVA的重均分子量（M _w））可以实现水凝胶性能的优化。讨论了每个因素对网络参数，机械，流变和表面性质，水凝胶孔隙率和透皮吸收的作用。使用0.25 wt％的DAC和PVA与M _w制备的水凝胶薄膜获得了最佳结果 = 130 kDa，具有高孔隙率和载药量（高含水量），机械特性易于处理，所有测试样品对皮肤的最佳附着力，并且改善了透皮药物传递能力。水凝胶膜具有生物相容性，没有细胞毒性，并且在存在时对细胞生长和形态没有负面影响。此外，水凝胶不支持细胞迁移和附着在其表面上，这应确保即使使用后也能从受伤或受损的皮肤上轻松去除水凝胶贴剂。