The transition period is one of the most challenging times for dairy cattle. Previous research suggests that treatment of postpartum cows with anti-inflammatory drugs may decrease pain and inflammation, enhancing cow welfare and performance during this challenging period. However, these strategies involve numerous time-consuming interventions, which require extra labor and do not fit modern farm logistics. The objective of this experiment was to assess the effects of acetylsalicylic acid (ASA) every 24 h for 2 d after calving on (1) daily milk yield, daily milk conductivity, and daily rumination during the first 60 days in milk (DIM), and 305-d mature-equivalent milk, milk fat, and milk protein yields, (2) body condition score, β-hydroxybutyrate (BHB), and haptoglobin, and (3) incidence of clinical diseases during the first 60 DIM. Dairy cows (n = 246) from a dairy farm located in Pennsylvania were enrolled in this experiment. Cows were blocked by parity and assigned randomly to 1 of 2 treatments: (1) ASA (n = 121), in which cows received 2 treatments with ASA (200 mg/kg; 4 boluses), the first within 12 h after parturition and the second 24 h later; or (2) untreated (UNT; n = 125), in which cows remained untreated. Blood samples were collected at 30 ± 6 h, 7 ± 3 d, and 14 ± 3 d after calving to measure BHB and haptoglobin concentrations. Body condition score was assessed at enrollment, 7 ± 3 DIM, 14 ± 3 DIM, and 50 ± 10 DIM. Furthermore, incidences of diseases, daily rumination, daily milk yield, and daily milk conductivity during the first 60 DIM and 305-d mature-equivalent milk, milk fat, and milk protein yields were collected from on-farm computer records. The data were analyzed using mixed multiple linear and logistic regression models as a randomized complete block design. Multiparous cows treated with ASA produced 1.64 kg/d more milk compared with multiparous cows that remained untreated (ASA = 41.66 ± 0.88 kg/d; UNT = 40.02 ± 0.81 kg/d) during the first 60 DIM. There was no difference in daily milk conductivity and rumination between treatments. Cows treated with ASA had lower concentration of BHB (ASA = 1.16 ± 0.64 mmol/L; UNT = 1.23 ± 0.80 mmol/L) during the first 14 ± 3 DIM and had higher body condition score within the first 50 ± 10 DIM compared with cows that remained UNT. There were no differences in circulating concentrations of haptoglobin between treatments. These results support previous findings showing that the use of anti-inflammatory drugs after calving may increase milk production and affect the metabolic status of dairy cows.

过渡时期是奶牛最具挑战性的时期之一。先前的研究表明，在此艰难时期，用抗炎药治疗产后母牛可以减轻疼痛和炎症，增强母牛的福利和性能。但是，这些策略涉及大量耗时的干预措施，这需要额外的劳动力并且不适合现代农场物流。该实验的目的是评估产犊后每2小时每隔24 h乙酰水杨酸（ASA）对（1）牛奶（DIM）的前60天每天的产奶量，每日的牛奶电导率和每日反刍作用的影响，以及305天的成熟当量牛奶，牛奶脂肪和牛奶蛋白质产量，（2）身体状况评分，β-羟基丁酸酯（BHB）和触觉珠蛋白，以及（3）前60个DIM期间的临床疾病发生率。该实验来自宾夕法尼亚州一个奶牛场的奶牛（n = 246）。母牛被均等性阻断，并随机分配到2种治疗方法中的一种：（1）ASA（n = 121），其中母牛接受2种ASA（200 mg / kg; 4次大剂量）的治疗，第一次是在分娩后12小时内进行，第二个24小时后；或（2）未经处理（UNT； n = 125），其中母牛未经处理。产犊后30±6 h，7±3 d和14±3 d采集血样，以测量BHB和触珠蛋白的浓度。入组时评估身体状况评分，分别为7±3 DIM，14±3 DIM和50±10 DIM。此外，还从农场的计算机记录中收集了前60个DIM和305天成熟当量的牛奶，牛奶脂肪和牛奶蛋白质产量期间的疾病，每日反刍，每日牛奶产量和每日牛奶电导率的发生率。使用混合的多个线性和逻辑回归模型作为随机完整模块设计来分析数据。在最初的60天DIM中，与未处理的多头母牛（ASA = 41.66±0.88 kg / d； UNT = 40.02±0.81 kg / d）相比，用ASA处理的多头母牛的产奶量增加了1.64 kg / d。处理之间的每日牛奶电导率和反刍力没有差异。在最初的14±3 DIM期间，用ASA处理的母牛的BHB浓度较低（ASA = 1.16±0.64 mmol / L； UNT = 1.23±0.80 mmol / L），并且在最初50±10 DIM内的身体状况评分较高。仍然是UNT的母牛。治疗之间的触珠蛋白循环浓度没有差异。