General control of amino acid synthesis 5 like 1 (GCN5L1) was named due to its loose sequence alignment to GCN5, a catalytic subunit of numerous histone N-acetyltransferase complexes. Further studies show that GCN5L1 has mitochondrial and cytosolic isoforms, although functional-domain sequence alignment and experimental studies show that GCN5L1 itself does not possess intrinsic acetyltransferase activity. Nevertheless, GCN5L1 does support protein acetylation in the mitochondria and cytosol and functions as a subunit of numerous intracellular multiprotein complexes that control intracellular vacuolar organelle positioning and function. The majority of GCN5L1 studies have focused on distinct intracellular functions and in this review, we summarize these findings as well as postulate what may be common features of the diverse phenotypes linked to GCN5L1.

氨基酸合成通用控制 5 样 1 (GCN5L1) 因其与 GCN5（众多组蛋白N-乙酰转移酶复合物的催化亚基）的松散序列比对而得名。进一步的研究表明，GCN5L1 具有线粒体和胞质亚型，尽管功能域序列比对和实验研究表明 GCN5L1 本身不具有内在的乙酰转移酶活性。尽管如此，GCN5L1 确实支持线粒体和细胞质中的蛋白质乙酰化，并作为众多细胞内多蛋白复合物的亚基发挥作用，控制细胞内液泡细胞器的定位和功能。大多数 GCN5L1 研究都集中在不同的细胞内功能，在这篇综述中，我们总结了这些发现，并假设与 GCN5L1 相关的不同表型的共同特征。