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Efficiency evaluation of the photocatalytic degradation of telmisartan anti-hypertensive drug with Fenton, photo-Fenton and recyclable TiO 2 heterogeneous catalyst
Reaction Kinetics, Mechanisms and Catalysis ( IF 1.8 ) Pub Date : 2020-06-26 , DOI: 10.1007/s11144-020-01806-8
A. Raji , K. N. Pandiyaraj , V. Kandavelu , D. Vasu , D. Saravanan

The photocatalytic degradation of telmisartan (TN), an anti-hypertensive drug was studied in aqueous media using different catalysts (Fenton, photo-Fenton and Titania (TiO2)) and different atmospheric conditions (air, oxygen (O2), air/hydrogen peroxide (air/H2O2), Oxygen/hydrogen peroxide O2/H2O2). In addition, the degradation experiments were also carried out using telmisartan based commercial tablets. The concentration of telmisartan during the degradation process was monitored by UV–Vis spectrophotometer. It has been found that O2/H2O2 atmospheric condition and into the presence of TiO2 shows higher degradation rate. The degradation was followed by pseudo-first order kinetics. The effect of various operating parameters such as concentration of telmisartan, dosage of the catalyst, pH and nature of irradiation was systematically studied. The mineralization trend of telmisartan was followed by TOC (total organic carbon) content and it was observed that complete mineralization could be achieved within a period of 3 h. The telmisartan metabolites or by-products during the degradation were analyzed and identified by GC–MS technique.



中文翻译:

Fenton,光-Fenton和可回收的TiO 2非均相催化剂对替米沙坦降压药物光催化降解的效率评估

在水性介质中使用不同的催化剂(芬顿,光芬顿和二氧化钛(TiO 2))和不同的大气条件(空气,氧气(O 2),空气/空气/水/水)对替米沙坦(TN)的光催化降解进行了研究。过氧化氢(空气/ H 2 O 2),氧/过氧化氢O 2 / H 2 O 2)。另外,还使用基于替米沙坦的市售片剂进行了降解实验。紫外-可见分光光度计监测降解过程中替米沙坦的浓度。已经发现O 2 / H 2 O 2在大气条件下并加入TiO 2表现出较高的降解速率。降解之后是伪一级动力学。系统地研究了诸如替米沙坦的浓度,催化剂的用量,pH值和辐射性质等各种操作参数的影响。替米沙坦的矿化趋势由总有机碳(TOC)含量决定,并观察到可以在3小时内完全矿化。通过GC-MS技术分析并鉴定了降解过程中的替米沙坦代谢产物或副产物。

更新日期:2020-06-26
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