Background

Recent medical advances have enabled the control of neurological symptoms and increased survival of patients with myasthenia gravis (MG). However, MG has many veiled consequences that may be underestimated by neurologists. Our aim was to clarify the social, professional, and neuropsychiatric issues of MG patients.

Methods

We carried out a cross-sectional cohort study with MG patients from a university-affiliated referral hospital. We registered clinical and sociodemographic data, and patients were classified according the MGFA classification. Clinical severity was assessed with Myasthenia Gravis Composite (MGC) scale. Trained and blind investigators analyzed social and professional outcomes. Neuropsychiatric symptoms were evaluated with the Hospital Anxiety and Depression Scale (HADS) and the social support with the Multidimensional Scale of Perceived Social Support (MSPSS).

Results

We enrolled 49 patients with MG. The mean age was 45.3 ± 18.1 years and 39 (79.6%) were women. There were 19 (38.8%) patients who become unemployed, 23 (46.9%) who had to retire prematurely, 31 (63.3%) that reported a significant reduction in work performance, and 23 (46.9%) who had a reduction in monthly income after the diagnosis of MG. Only 16 (32.6%) received any financial support and 24 (48.9%) patients had the perception of receiving a satisfactory social support. The practice of physical activity is a habit in only 10 patients (20.4%). Neuropsychiatric symptoms were present in 26 (53.1%) patients.

Conclusion

Patients with MG are vulnerable to social, professional, and mental disadvantages. Therapeutic success in MG goes beyond symptom relief and inevitably depends on a personalized approach to the patient.

中文翻译：

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重症肌无力患者的社会，专业和神经精神病学预后。

背景

最近的医学进步已使控制神经系统症状和增加重症肌无力（MG）患者的生存。但是，MG有许多隐蔽的后果，神经科医生可能会低估它。我们的目的是阐明MG患者的社会，专业和神经精神病学问题。

方法

我们对来自大学附属转诊医院的MG患者进行了横断面队列研究。我们注册了临床和社会人口统计学数据，并根据MGFA分类对患者进行了分类。临床严重程度使用重症肌无力综合量表（MGC）进行评估。受过训练的盲人调查员分析了社会和专业成果。使用医院焦虑和抑郁量表（HADS）评估神经精神症状，并使用感知社会支持多维量表（MSPSS）评估社会支持。

结果

我们招募了49名MG患者。平均年龄为45.3±18.1岁，女性为39岁（79.6％）。有19名（38.8％）失业的患者，23名（46.9％）的必须提前退休，31名（63.3％）的工作表现明显下降，23名（46.9％）的月收入下降确诊为MG后。只有16名（32.6％）获得了任何经济支持，而24名（48.9％）的患者获得了令人满意的社会支持。只有10名患者（20.4％）习惯进行体育锻炼。26例（53.1％）患者出现神经精神症状。

结论

MG患者容易受到社交，专业和精神上的不利影响。MG的治疗成功不仅可以缓解症状，而且不可避免地取决于患者的个性化治疗方法。