Background

COVID-19 is a virus pandemic. According to the first obtained data, COVID-19 has defined with findings such as cough, fever, diarrhea, and fatigue although neurological symptoms of patients with COVID-19 have not been investigated in detail. This study aims to investigate the neurological findings via obtained face-to-face anamnesis and detailed neurological examination in patients with COVID-19.

Methods

Two hundred thirty-nine consecutive inpatients with COVID-19, supported with laboratory tests, were evaluated. Detailed neurological examinations and evaluations of all patients were performed. All evaluations and examinations were performed by two neurologists who have at least five-year experience.

Results

This study was carried out 239 patients (133 male + 106 female) with diagnosed COVID-19. Neurological findings were present in 83 of 239 patients (34.7%). The most common neurological finding was a headache (27.6%). D-dimer blood levels were detected to be significantly higher in patients with at least one neurological symptom than patients without the neurological symptom (p < 0.05). IL-6 level was found to be significantly higher in patients with headache than without headache (p < 0.05). Creatine kinase (CK) level was detected to be significantly higher in patients with muscle pain (p < 0.05).

Conclusion

Neurological symptoms are often seen in patients with COVID-19. Headache was the most common seen neurological symptom in this disease. Dizziness, impaired consciousness, smell and gustation impairments, cerebrovascular disorders, epileptic seizures, and myalgia were detected as other findings apart from the headache. It is suggested that determining these neurological symptoms prevents the diagnosis delay and helps to prohibit virus spread.

中文翻译：

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COVID-19 患者详细神经系统表现的前瞻性临床研究。

背景

COVID-19 是一种病毒大流行。根据获得的第一个数据，COVID-19 已定义为咳嗽、发烧、腹泻和疲劳等发现，尽管尚未详细调查 COVID-19 患者的神经系统症状。本研究旨在通过获得 COVID-19 患者的面对面病史和详细的神经系统检查来调查神经系统检查结果。

方法

在实验室测试的支持下，对 239 名 COVID-19 连续住院患者进行了评估。对所有患者进行了详细的神经系统检查和评估。所有评估和检查均由两名至少有五年经验的神经科医生进行。

结果

本研究对 239 名确诊为 COVID-19 的患者（133 名男性 + 106 名女性）进行。239 名患者中有 83 名（34.7%）有神经系统检查结果。最常见的神经系统发现是头痛（27.6%）。至少有一种神经系统症状的患者检测到 D-二聚体血液水平显着高于没有神经系统症状的患者（p  < 0.05）。发现头痛患者的 IL-6 水平显着高于无头痛患者（p  < 0.05）。肌痛患者的肌酸激酶（CK）水平显着升高（p  < 0.05）。

结论

COVID-19 患者经常出现神经系统症状。头痛是本病最常见的神经系统症状。除了头痛之外，还发现了头晕、意识障碍、嗅觉和味觉障碍、脑血管疾病、癫痫发作和肌痛。建议确定这些神经系统症状可以防止诊断延迟并有助于阻止病毒传播。