Abstract

In this study, BT@ZnO:Yb heterostructures prepared using the combined sol-gel-hydrothermal methods were coated with chitosan (Qo) to obtain a hybrid heterostructure [BT@ZnO:Yb]-Qo. The structure, particle morphology, luminescence properties, and cytotoxicity of the hybrid heterostructure are discussed. X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infra-red (FT-IR) as well as Raman and photoluminescence spectra, were used for characterisation and monitoring of the heterostructure formation process. The results reveal the formation of the BT@ZnO:Yb heterostructure, and are consistent with the relative intensities and positions of peaks in the XRD spectra of BT and ZnO:Yb, with the average particle size of ~75 nm. Effective Qo coating was achieved and a narrow, well-defined, and high-intensity luminescence signal was detected at ~610 nm for all the analysed samples. In vitro studies suggested that treatment with 1 µg/ml BT@ZnO:Yb 3 mol% induced very low cytotoxicity on HeLa cells.

The morphologie of the [BT@ZnO:Yb]-Qo heterostructures shows that the Nps were uniformly distributed throughout the Qo matrix, with the average particle diameter of ~80 nm with the tennis-ball-like spheres after the incorporation of chitosan. The prepared hybrid heterostructures exhibited a narrow, well-defined, and high-intensity luminescence peak at ~610 nm for all the analysed samples, and low cytotoxicity at 1 μg/ml.

中文翻译：

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BaTiO 3 @ZnO：Yb异质结构的壳聚糖涂层：合成与性能

摘要

在这项研究中，使用壳聚糖（Qo）涂覆通过溶胶-凝胶-水热联合方法制备的BT @ ZnO：Yb异质结构以获得杂化结构[BT @ ZnO：Yb] -Qo。讨论了杂种杂化结构的结构，颗粒形态，发光特性和细胞毒性。X射线衍射（XRD），扫描电子显微镜（SEM），透射电子显微镜（TEM），傅立叶变换红外（FT-IR）以及拉曼光谱和光致发光光谱用于表征和监测异质结构的形成处理。结果揭示了BT @ ZnO：Yb异质结构的形成，并且与BT和ZnO：Yb的XRD光谱中峰的相对强度和位置一致，平均粒径为〜75 nm。实现了有效的Qo涂层，并且狭窄，轮廓分明，。体外研究表明，使用1 µg / ml 3 mol％的BT @ ZnO：Yb进行治疗对HeLa细胞的细胞毒性非常低。

[BT @ ZnO：Yb] -Qo异质结构的形态表明，Nps均匀地分布在整个Qo基质中，加入壳聚糖后，网球样球的平均粒径约为80 nm。对于所有分析的样品，制备的杂种异质结构均在〜610 nm处显示出狭窄，轮廓分明的高强度发光峰，在1μg/ ml时细胞毒性较低。