Molar pregnancies are benign trophoblastic diseases associated with a risk of malignant transformation. If aetiology remains mostly unknown, the risk of recurrent molar pregnancy is around 1.5% after one molar pregnancy and around 25% after 2 molar pregnancies. In the later situation, genetic mutations have been described, increasing hugely this risk. In case of mutations, probability to obtain a normal pregnancy is estimated around 1.8%. We report the case of a Caucasian 30-year-old woman whose previous five spontaneous pregnancies had a negative outcome: a spontaneous miscarriage and then 4 complete hydatidiform moles. Genetic testing revealed that the patient carried two heterozygous mutations in the NLRP7 gene (c.2982-2A > G and Y318CfsX7). According to this, counselling was conducted to advocate for oocyte donation in order to obtain a normal pregnancy. This technique enabled a complication-free, singleton pregnancy that resulted in a healthy term live birth of a 2900 g female. Few months after delivery, the patient presented a new complete hydatidiform mole. Women presented with mutations in the NLRP7, KHDC3L or PADI6 genes are unlikely to obtain normal pregnancies, with a major risk of reproductive failure. In such a context, oocyte donation may be the best option. Only 4 normal pregnancies and deliveries have been published in this situation through this technique to our knowledge.

磨牙妊娠是与恶性转化风险相关的良性滋养细胞疾病。如果病因仍然大部分未知，那么在一次葡萄胎妊娠后复发性葡萄胎妊娠的风险约为 1.5%，在两次葡萄胎妊娠后约为 25%。在后一种情况下，已经描述了基因突变，极大地增加了这种风险。在发生突变的情况下，获得正常怀孕的概率估计约为 1.8%。我们报告了一名 30 岁白人女性的案例，她之前 5 次自然怀孕都有负面结果：自然流产，然后是 4 颗完整的葡萄胎。基因检测显示该患者在NLRP7 中携带两个杂合突变基因（c.2982-2A > G 和 Y318CfsX7）。据此，进行了咨询，倡导捐卵，以获得正常怀孕。该技术实现了无并发症的单胎妊娠，从而使 2900 克女性健康足月活产。分娩后几个月，患者出现了新的完全性葡萄胎。出现NLRP7、KHDC3L或PADI6基因突变的女性不太可能获得正常怀孕，并且存在生殖失败的主要风险。在这种情况下，捐卵可能是最好的选择。据我们所知，在这种情况下，仅通过这种技术发表了 4 例正常怀孕和分娩。