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Curcumin encapsulated colloidal amphiphilic block co-polymeric nanocapsules: colloidal nanocapsules enhance photodynamic and anticancer activities of curcumin.
Photochemical & Photobiological Sciences ( IF 2.7 ) Pub Date : 2020-06-25 , DOI: 10.1039/d0pp00032a Linda Bechnak 1 , Christian Khalil 2 , Riham El Kurdi 1 , Rony S Khnayzer 2 , Digambara Patra 1
Photochemical & Photobiological Sciences ( IF 2.7 ) Pub Date : 2020-06-25 , DOI: 10.1039/d0pp00032a Linda Bechnak 1 , Christian Khalil 2 , Riham El Kurdi 1 , Rony S Khnayzer 2 , Digambara Patra 1
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Curcumin-based novel colloidal nanocapsules were prepared from amphiphilic poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) (F108). These colloidal nanocapsules appeared as spherical particles with size ranging between 270 and 310 nm. Curcumin fluorescence spectra exhibited an aggregation-induced 23 nm red-shift of the emission maximum in addition to the enhancement of the fluorescence quantum yield in these nanocapsules. The cytotoxicity of curcumin and colloidal nanocapsules was assessed using human derived immortalized cell lines (A549 and A375 cells) in the presence and absence of light irradiation. The nanocapsules exhibited a >30-fold decrease in IC50, suggesting enhanced anticancer activity associated with curcumin encapsulation. Higher toxicity was also reported in the presence of light irradiation (as shown by the IC50 data), indicating their potential for future application in photodynamic therapy. Finally, A375 cells treated with curcumin and the nanocapsules showed a significant increase in single- and/or double-strand DNA breaks upon exposure to light, indicating promising biological effects.
中文翻译：
姜黄素包裹的胶体两亲性嵌段共聚物纳米胶囊：胶体纳米胶囊增强姜黄素的光动力和抗癌活性。
-基于姜黄素新颖胶体纳米胶囊从两亲性聚（环氧乙烷）中制备嵌段-聚（环氧丙烷） -嵌段-聚（环氧乙烷）（F108）。这些胶体纳米胶囊显示为球形颗粒，尺寸在270至310 nm之间。姜黄素荧光光谱显示出聚集诱导的发射最大值的23nm红移，除了增强了这些纳米胶囊中的荧光量子产率。在存在和不存在光照射的情况下，使用人源性永生化细胞系（A549和A375细胞）评估姜黄素和胶体纳米胶囊的细胞毒性。纳米胶囊的IC 50降低30倍以上，表明与姜黄素封装相关的抗癌活性增强。据报道，在有光照射的情况下，毒性更高（如IC 50数据所示），表明它们有可能在光动力疗法中进一步应用。最后，用姜黄素和纳米胶囊处理的A375细胞在暴露于光下后，单链和/或双链DNA断裂显着增加，表明其有望发挥生物学作用。
更新日期：2020-08-12
中文翻译：
姜黄素包裹的胶体两亲性嵌段共聚物纳米胶囊：胶体纳米胶囊增强姜黄素的光动力和抗癌活性。
-基于姜黄素新颖胶体纳米胶囊从两亲性聚（环氧乙烷）中制备嵌段-聚（环氧丙烷） -嵌段-聚（环氧乙烷）（F108）。这些胶体纳米胶囊显示为球形颗粒，尺寸在270至310 nm之间。姜黄素荧光光谱显示出聚集诱导的发射最大值的23nm红移，除了增强了这些纳米胶囊中的荧光量子产率。在存在和不存在光照射的情况下，使用人源性永生化细胞系（A549和A375细胞）评估姜黄素和胶体纳米胶囊的细胞毒性。纳米胶囊的IC 50降低30倍以上，表明与姜黄素封装相关的抗癌活性增强。据报道，在有光照射的情况下，毒性更高（如IC 50数据所示），表明它们有可能在光动力疗法中进一步应用。最后，用姜黄素和纳米胶囊处理的A375细胞在暴露于光下后，单链和/或双链DNA断裂显着增加，表明其有望发挥生物学作用。
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