A new extraction method is proposed for the isolation of the histamine H₂ receptor antagonist ranitidine (RNT) from aqueous samples. For this purpose, a low solvent consumption method using ultrasound-assisted emulsification microextraction (USAEME) was proposed. Ionic liquids (IL), such as 1-butyl-3-methylimidazolium hexafluorophosphate [C₄mim][PF₆] and 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide [C₄mim][Tf₂N], were used for the isolation of ranitidine. The microextraction parameters of the studied antihistaminic drug, namely, volume of extractant, pH of the sample and shaking time were optimized. The influence of foreign substances on the isolation process was tested. The separation of RNT using the IL-USAEME method enables the effective extraction and preconcentration of this analyte. The ionic liquid extracts after ultrasound-assisted emulsification microextraction were determined by spectrophotometry (UV) and high performance liquid chromatography (HPLC-UV) methods. The precision of procedures developed for the determination of the studied H₂ receptor antagonist ranged from 0.8% to 4.2%. These methods, USAEME-UV and USAEME-HPLC-UV, enable the detection of ranitidine in real samples at levels of 3 × 10⁻⁶ mol L⁻¹ and 1 × 10⁻⁷ mol L⁻¹, respectively. The developed procedures were applied for the determination of ranitidine in river water and pharmaceutical preparations.

中文翻译：

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基于离子液体的超声辅助乳化微萃取法测定水样和药物制剂中的雷尼替丁

提出了一种新的提取方法，用于从含水样品中分离出组胺H ₂受体拮抗剂雷尼替丁（RNT）。为此，提出了一种使用超声辅助乳化微萃取（USAEME）的低溶剂消耗方法。离子液体（IL），例如1-丁基-3-甲基咪唑六氟磷酸盐[C ₄ mim] [PF ₆ ]和1-丁基-3-甲基咪唑鎓双（三氟甲基磺酰基）酰亚胺[C ₄ mim] [Tf ₂N 1，用于雷尼替丁的分离。优化了所研究的抗组胺药物的微萃取参数，即萃取剂的体积，样品的pH和振荡时间。测试了异物对分离过程的影响。使用IL-USAEME方法分离RNT可以有效萃取和预浓缩该分析物。通过分光光度法（UV）和高效液相色谱（HPLC-UV）方法测定超声辅助乳化微萃取后的离子液体提取物。为确定所研究的H ₂受体拮抗剂而开发的程序的精确度为0.8％至4.2％。这些方法，USAEME-UV和USAEME-HPLC-UV，能够以3×10的水平检测真实样品中的雷尼替丁^-6 mol L ^-1和1×10 ^-7 mol L ^-1。所开发的方法用于测定河水中和药物制剂中的雷尼替丁。