A smart theranostic agent based on Fe-HPPy@Au/DOX for CT imaging and PTT/chemotherapy/CDT combined anticancer therapy.,Biomaterials Science

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A smart theranostic agent based on Fe-HPPy@Au/DOX for CT imaging and PTT/chemotherapy/CDT combined anticancer therapy.
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-06-25 , DOI: 10.1039/d0bm00623h
Xijian Liu ₁ , Minyi Zhang , Dawei Yan , Guoying Deng , Qi Wang , Chunlin Li , Linjing Zhao , Jie Lu

Affiliation

We herein explored a smart Fe-HPPy@Au/DOX theranostic agent for CT diagnosis and PTT/chemotherapy/CDT synergistic treatment of cancer. When the Fe-HPPy@Au/DOX theranostic agent entered the tumor, the tumor environment accelerated the trapped Fe ions release to catalyze the production of ˙OH for CDT. NIR irradiation drove the PTT, and at the same time improved the CDT by increasing the production of ˙OH and triggered DOX release for chemotherapy. In addition, the Au nanoparticles on the surface of Fe-HPPy@Au nanocomposites could be used as a CT imaging agent and catalyzer to produce H₂O₂ for enhanced CDT.

中文翻译：

基于Fe-HPPy @ Au / DOX的智能化治疗药物，用于CT成像和PTT /化学疗法/ CDT联合抗癌治疗。

我们在本文中探索了一种智能的Fe-HPPy @ Au / DOX治疗试剂，用于CT诊断和PTT /化学疗法/ CDT协同治疗癌症。当Fe-HPPy @ Au / DOX治疗试剂进入肿瘤时，肿瘤环境加速了捕获的Fe离子的释放，从而催化了CDT的˙OH的产生。NIR辐照驱动了PTT，同时通过增加˙OH的产生并触发了化学疗法的DOX释放而改善了CDT。此外，Fe-HPPy @ Au纳米复合材料表面的Au纳米颗粒可以用作CT显像剂和催化剂，以产生H ₂ O ₂来增强CDT。

更新日期：2020-07-28

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