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Multicomponent Reaction of Phosphines, Benzynes, and CO2: Facile Synthesis of Stable Zwitterionic Phosphonium Inner Salts.
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2020-06-25 , DOI: 10.1021/acs.joc.0c00745
Pei Xie 1 , Shoushan Yang 1 , Yuyu Guo 1 , Zhihua Cai 1 , Bin Dai 1 , Lin He 1
Affiliation  

The first synthesis of benzyne-derived stable zwitterions is reported. Benzynes generated in situ from 2-(trimethylsilyl)aryl triflates undergo a multicomponent reaction with phosphines and CO2 to produce the stable 1,5-zwitterionic species in moderate to excellent isolated yields, which provides a novel method for the preparation of phosphonium inner salts under mild and transition-metal-free conditions.

中文翻译:

膦,苯并和二氧化碳的多组分反应:稳定的两性离子w内盐的简便合成。

据报道,苯并炔衍生的稳定两性离子的首次合成。由2-(三甲基甲硅烷基)芳基三氟甲磺酸原位生成的苯并zy与膦和CO 2进行多组分反应,以稳定的至极好的分离产率生成稳定的1,5-两性离子物质,这为制备inner内盐提供了一种新方法在无过渡金属的温和条件下。
更新日期:2020-07-17
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