The purpose of this study was to detect clinical variations between lung adenocarcinoma patients with and without ocular metastasis (OM) to identify risk factors for OM and assess the diagnostic values. We included 1153 patients with lung adenocarcinoma in this study. Independent -tests and chi-square tests were used to compare patients’ clinical characteristics. Statistically significant parameters were analyzed by binary logistic regression to detect risk factors of OM. The results showed that the OM group had increased alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), cytokeratin fragment 19 (CYFRA 21-1), carbohydrate antigen- (CA-) 125, CA-153, and total prostate-specific antigen (TPSA) compared with the NOM group. CYFRA21-1 is the most useful biomarker for detecting OM in this population.

中文翻译：

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血清肿瘤标志物预测肺腺癌眼转移的评估：一项回顾性研究。

这项研究的目的是检测有无眼转移（OM）的肺腺癌患者之间的临床差异，以鉴定OM的危险因素并评估其诊断价值。在这项研究中，我们纳入了1153例肺腺癌患者。独立-检验和卡方检验来比较患者的临床特点。通过二元logistic回归分析统计显着性参数，以检测OM的危险因素。结果显示OM组的甲胎蛋白（AFP），癌胚抗原（CEA），细胞角蛋白片段19（CYFRA 21-1），碳水化合物抗原（CA-）125，CA-153和总前列腺特异性增加抗原（TPSA）与NOM组相比。CYFRA21-1是检测该人群中OM的最有用的生物标志物。