Stem cells tightly link their metabolism to cell fate decisions; however, how cancers co-opt and bypass metabolic pathways for growth advantage remains unclear. New evidence in this issue highlights how cancer stem cells avoid epigenetically driven differentiation by shutting down endogenous serine synthesis and becoming serine auxotrophs.

中文翻译：

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挨饿得感冒，也许还得癌症。


干细胞的新陈代谢与细胞命运的决定紧密相连；然而，癌症如何利用和绕过代谢途径以获得生长优势仍不清楚。本期的新证据强调了癌症干细胞如何通过关闭内源丝氨酸合成并成为丝氨酸营养缺陷型细胞来避免表观遗传驱动的分化。