Functionalized Carbon Nanotube-Embedded Poly(vinyl alcohol) Microspheres for Efficient Removal of Tumor Necrosis Factor-α,ACS Biomaterials Science & Engineering

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Functionalized Carbon Nanotube-Embedded Poly(vinyl alcohol) Microspheres for Efficient Removal of Tumor Necrosis Factor-α
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-06-24 , DOI: 10.1021/acsbiomaterials.9b01916
Jian Chen _{1,

2} , Lichun Wang ₁ , Tingting Wang ₁ , Chunran Li ₁ , Wenyan Han ₁ , Yamin Chai ₁ , Zhuang Liu ₁ , Lailiang Ou ₁ , Wenzhong Li _{2,

3}

Affiliation

Tumor necrosis factor (TNF)-α has an important role in the pathogenesis of autoimmune and inflammatory diseases such as rheumatoid and septic arthritis. Removal of excess tumor necrosis factor-α (TNF-α) is a promising treatment. In this study, a series of functionalized carbon nanotube-embedded poly(vinyl alcohol) (PVA) nanocomposite adsorbents were prepared for TNF-α removal for the first time. The resulting nanocomposites were characterized by scanning electron microscopy and Raman spectroscopy, which demonstrated that carbon nanotubes were well-dispersed on the surface of PVA macroporous microspheres. Adsorption tests showed that the carboxylated carbon nanotube-embedded composite microspheres (PVA/MWCNTs-COOH) possessed much better adsorption capacity for TNF-α in both simulated serum solution and rat plasma compared to the aminated (PVA/MWCNTs-NH₂) and raw carbon nanotube-embedded microspheres (PVA/MWCNTs-raw). In addition, the effects on hemolytic activity, the anticoagulant property, and the components of blood were negligible, indicating the excellent blood compatibility of composite beads. Our findings suggest that the carboxylated carbon nanotube-embedded composite microspheres may be potentially useful for the treatment of autoimmune and inflammatory diseases by removing TNF-α from the blood.

中文翻译：

功能化碳纳米管嵌入式聚乙烯醇微球有效去除肿瘤坏死因子-α

肿瘤坏死因子（TNF）-α在自身免疫和炎性疾病（如类风湿和败血性关节炎）的发病机理中具有重要作用。去除多余的肿瘤坏死因子-α（TNF-α）是一种有前途的治疗方法。在这项研究中，首次制备了一系列功能化的嵌入碳纳米管的聚乙烯醇（PVA）纳米复合材料吸附剂，以去除TNF-α。所得纳米复合材料通过扫描电子显微镜和拉曼光谱进行表征，表明碳纳米管很好地分散在PVA大孔微球表面上。₂）和嵌入碳纳米管的原始微球（PVA / MWCNTs-raw）。另外，对溶血活性，抗凝性和血液成分的影响可忽略不计，表明复合珠具有优异的血液相容性。我们的发现表明，通过从血液中去除TNF-α，羧化碳纳米管嵌入的复合微球可能潜在地用于治疗自身免疫和炎症性疾病。

更新日期：2020-08-10

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