The increasing evidence supports the fact that lactate in the tumor microenvironment (TME) plays a vital role in tumor proliferation, metastasis, and recurrence, which in turn is emerging as one of the most interesting molecular targets for tumor treatment. Here, hierarchical porous zeolitic imidazolate framework-8 (ZIF-8) as the nanocarrier is fabricated to simultaneously load lactate oxidase (LOD) and Fe₃O₄ nanoparticles (NPs), called LOD & Fe₃O₄@ZIF-8 NPs (LFZ NPs), for tumor therapy. On one hand, the sharp consumption of lactate in the TME by LOD will change the essential “soil” where tumor cells live so as to suppress tumor rapid growth. On the other hand, hydrogen peroxide (H₂O₂) is produced in the TME from the oxidation of lactate catalyzed by LOD and subsequently converted to highly toxic hydroxyl radicals (^•OH) catalyzed by Fe₃O₄ NPs via Fenton-like reactions to kill tumor cells. Based on the endogenous catalysis, this dual-modal strategy of tumor therapy based on lactate is simple, safe, and effective, which deserves to be well concerned.

中文翻译：

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乳酸氧化酶嵌入的分层多孔沸石沸石咪唑酸盐骨架的双峰治疗作用作为有效抑制肿瘤的纳米催化剂。

越来越多的证据支持这样的事实，即乳酸在肿瘤微环境（TME）中在肿瘤增殖，转移和复发中起着至关重要的作用，而反过来，乳酸又正成为肿瘤治疗中最有趣的分子靶标之一。在这里，制备了作为纳米载体的分层多孔沸石咪唑酸酯骨架8（ZIF-8），以同时加载乳酸氧化酶（LOD）和Fe ₃ O ₄纳米颗粒（NPs），称为LOD和Fe ₃ O ₄ @ ZIF-8 NPs（ LFZ NPs），用于肿瘤治疗。一方面，LOD在TME中大量消耗乳酸会改变肿瘤细胞所处的基本“土壤”，从而抑制肿瘤的快速生长。另一方面，过氧化氢（H ₂ O ₂）是由LOD催化的乳酸氧化而在TME中产生的，随后通过Fenton样反应转化为Fe ₃ O ₄ NP催化的高毒性羟基自由基（^• OH），从而杀死肿瘤细胞。基于内源性催化作用，这种基于乳酸的肿瘤双峰治疗策略简单，安全，有效，值得人们高度关注。