Abstract

The research was performed to study the mechanism whereby histamine affects the profile of plasma lipids. Six groups of ten male rats were received two injections with histamine or its H1- and H2-agonists and antagonists. Histamine caused a significant decrease in the concentrations of triglyceride, total cholesterol, and LDLc, while HDLc had no significant change. The rate of VLDL secretion was 263.6 ± 25.8 mg/h dL in control rats and was inhibited by about 68% in histamine injected rats. These changes have been mimicked by either histamine H1- or H2-agonists. The effects of H1- and H2-agonists were abolished in the presence of cetirizine and famotidine respectively. Histamine causes a significant decrease in serum triglyceride, total, and LDL-cholesterol by both H1 and H2-receptors. The decrease in serum lipids is due to the inhibitory effect of histamine or its agonists on VLDL secretion from the liver.

摘要

该研究旨在研究组胺影响血浆脂质分布的机制。六组十只雄性大鼠接受两次组胺或其H1-和H2-激动剂和拮抗剂注射。组胺引起甘油三酯、总胆固醇和低密度脂蛋白浓度的显着降低，而高密度脂蛋白没有显着变化。VLDL 分泌率在对照大鼠中为 263.6 ± 25.8 mg/h dL，在注射组胺的大鼠中被抑制了约 68%。这些变化已被组胺 H1 或 H2 激动剂模仿。H1-和H2-激动剂的作用分别在西替利嗪和法莫替丁存在下被取消。组胺通过 H1 和 H2 受体导致血清甘油三酯、总胆固醇和低密度脂蛋白胆固醇显着降低。