Abstract The main therapeutic strategy currently used for acute myocardial infarction (AMI) is to open occluded coronary arteries, a process defined as blood reperfusion. However, blood reperfusion will increase cardiac mortality, tissue damage and cardiac dysfunction in patients with AMI, which is mechanically defined as "ischemia/reperfusion (I/R) injury". It is currently believed that mitochondrial dynamics plays a key role in myocardial I/R, especially excessive mitochondrial fission, which is the main cause of cardiac dysfunction. Therefore, in the process of I/R injury, effective drug intervention and correct treatment strategies can be used to regulate mitochondrial dynamic balance to combat ischemia-reperfusion injury, which can play a huge role in improving the prognosis of patients. This review summarized the effects of mitochondrial fission and mitochondrial fusion balance on myocardial and mitochondrial functional changes during myocardial I/R injury. Finally, combined with the previous injury mechanisms, this review also briefly described some drug intervention that may be beneficial to clinical practice to improve the postoperative quality of life of patients with AMI.

中文翻译：

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线粒体情景：线粒体动力学在急性心肌缺血/再灌注损伤中的作用

摘要 目前用于急性心肌梗死 (AMI) 的主要治疗策略是打开闭塞的冠状动脉，这一过程被定义为血液再灌注。然而，血液再灌注会增加AMI患者的心脏死亡率、组织损伤和心功能不全，这在机械上被定义为“缺血/再灌注（I/R）损伤”。目前认为线粒体动力学在心肌 I/R 中起关键作用，尤其是过度的线粒体裂变，这是导致心功能不全的主要原因。因此，在I/R损伤过程中，可以通过有效的药物干预和正确的治疗策略来调节线粒体动态平衡，对抗缺血再灌注损伤，对改善患者的预后具有巨大的作用。本综述总结了线粒体裂变和线粒体融合平衡对心肌 I/R 损伤过程中心肌和线粒体功能变化的影响。最后，结合以往的损伤机制，本综述还简要描述了一些可能有益于临床实践以提高AMI患者术后生活质量的药物干预。