Foot-and-mouth disease (FMD) is an economically important contagious disease of livestock mainly cattle, buffalo, sheep, goats, and pig. There is limited data available on pathogenesis of foot and mouth disease in goats. In the study, the sheep and goats were infected experimentally with a serotype O foot-and-mouth disease virus by different challenge routes. The sheep and goats challenged by coronary band route and coronary band and intra-dermo-lingual route exhibited FMD clinical signs at 2–5 days post challenge. Whereas intra-dermo-lingual challenged sheep and goats did not exhibit FMD clinical signs. Live virus could be isolated from blood of infected sheep and goats at 2–5 days post challenge. Viral RNA could be detected from blood of infected sheep and goats at 1–10 days post challenge. The neutralizing antibody titre was detected at 10 days post challenge and maintained up to 35 days post challenge in all infected sheep and goats. Non structural protein (NSP) antibodies were detected as early as 5–10 days post challenge and remain positive up to 35 days post challenge in the infected sheep and goats. In conclusion, the pathogenesis of sheep and goats with serotype O foot and mouth disease virus by different challenge routes could be demonstrated.

口蹄疫（FMD）是一种经济上重要的牲畜传染病，主要是牛，水牛，绵羊，山羊和猪。关于山羊手足口病发病机理的可用数据有限。在这项研究中，绵羊和山羊通过不同的攻击途径实验性感染了血清型O型口蹄疫病毒。被冠状动脉带途径，冠状动脉带和真皮内舌途径攻击的绵羊和山羊在攻击后2至5天表现出FMD临床症状。而经皮舌内攻击的绵羊和山羊没有FMD的临床体征。攻击后2至5天，可以从感染的绵羊和山羊的血液中分离出活病毒。攻击后1-10天可从感染的绵羊和山羊的血液中检测到病毒RNA。在攻击后10天检测到中和抗体滴度，并且在所有感染的绵羊和山羊中攻击后直至35天都保持中和抗体滴度。非结构蛋白（NSP）抗体最早在攻击后5-10天被检测到，并且在感染后的绵羊和山羊中直至攻击后35天仍保持阳性。总之，可以通过不同的攻击途径证明血清型O型口蹄疫病毒绵羊和山羊的发病机理。