Abstract Two meta-xylyl linked tetrakis-benzimidazolium salts (L1-L2) as multidentate ligands and two respective silver complexes (C1 and C2) were synthesized. A multistep reaction was done at room temperature, starting with simple benzimidazole and alkyl halides, going through precursors and salt formation by reflux and finally in situ deprotonation of tetrabenzimidazolium salts with Ag2O to yield respective tetra-nuclear Ag(I)-N-heterocyclic Carbene (NHC) complexes. Propyl and butyl groups were bonded at the terminal positions of tetra-azolium open chain salts. Characterization of compounds was done by analytical and spectroscopic techniques. On the basis of spectroscopic data, a chemical structure with open chains having four Ag(I) ions sandwiched between NHC layers was established. Potential of synthesized complexes (C1 & C2) for wound contraction was evaluated and compared with standard wound contraction gel. Percentage wound contraction of both complexes was found very close to that of standard drug used in parallel.

中文翻译：

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用于伤口愈合应用的夹心型无环四核银（I）-N-杂环卡宾配合物的合成

摘要 合成了两种间二甲苯基连接的四苯并咪唑鎓盐 (L1-L2) 作为多齿配体和两种各自的银配合物 (C1 和 C2)。在室温下进行多步反应，从简单的苯并咪唑和卤代烷开始，通过回流形成前体和盐，最后用 Ag2O 原位对四苯并咪唑盐进行去质子化，得到各自的四核 Ag(I)-N-杂环卡宾(NHC) 复合物。丙基和丁基键合在四唑鎓开链盐的末端位置。化合物的表征是通过分析和光谱技术完成的。根据光谱数据，建立了具有开链的化学结构，其中四个 Ag(I) 离子夹在 NHC 层之间。合成复合物的潜力（C1 & C2) 对伤口收缩进行了评估，并与标准伤口收缩凝胶进行了比较。发现两种复合物的伤口收缩百分比非常接近平行使用的标准药物的百分比。