The following paper "Glutamate activates GFAP gene promoter from cultured astrocytes through TGF‐β1 pathways" by Luciana Romão et al. (https://onlinelibrary.wiley.com/doi/full/10.1111/j.1471‐4159.2008.05428.x) is being corrected by agreement between the authors and the Editorial Office of the Journal of Neurochemistry.

The Editorial Office had been notified about duplications and inconsistencies in Figures 2 and 5 of the corrected paper, highlighted in the following figure:

The initial submission of the paper in November 2007 was followed by a revision of figures as per reviewer request. The manuscript was then published in 2008. The Editorial Office contacted the corresponding author Flávia Gomes and received the following explanation:

During the first round of revision, one of the reviewers suggested that Figures 4 and 5 of the submitted manuscript should be combined (Figure 5 in the published version). Figures 5b and 5f of the published manuscript are correct. They are exactly the same images submitted previously as Figure 5G and 5I (first submission). However, the lane with α‐TGF‐β1 has been removed (please see below in red square).

Figure 2 has been modified and part of Figure 5 of the first submitted version has been inappropriately incorporated into Figure 2 (lane α‐TGF). Four images of Figure 2 of the published manuscript are wrong (red X in image below). When preparing the modified version, the first author did not include the correct images already provided to the Journal as part of Figure 5 of the first version of submission. α‐TGF‐β1 lane in published Figure 2 (b, e , h) must be replaced by the α‐TGF‐β1 lane of Figure 5 of the first submission (see yellow, purple, and green square in the image below). Be aware of the different order of the columns between original Figure 5 (Control/Glutamate/TGF‐β1) and published Figure 2 (Control/TGF‐β1/Glu 100 μM). Originally published Figures 2a and 2c mistakenly showed the same condition (MCPG). Figure 2a is to be replaced by Figure 5a which is showing a correct control condition. Unfortunately, it was a mistake when preparing the second submission of the manuscript. After consulting the first author of the paper, she suggested fields from the same glass coverslip/well have been photographed and named incorrectly, by receiving names of different conditions (control and MCPG).

Note that the first line panels; a, d and g (Control/TGF‐β1/Glu 100 μM) are the same conditions (but different images) as already shown in Figure 5 of the published work (Control/Glutamate/TGF‐β1), respectively. It is worth to observe that there is no difference in the number of β‐gal positive cells between these two conditions (graphic). Further, quantifications have been done after detection of β‐galactosidase activity, directly at the microscopy (on site, not after imaging) (as described in the Materials and Methods); and images have been used to provide visual/representative illustration). The quantification graphic is the same provided in the version of the first submission. Although this fact does not minimize the seriousness of our mistake, we would like to guarantee that it does not impact the main conclusions of the paper.

The instances are again summarized in the following table provided by the author:

The publication is therefore corrected in that Figure 2a is replaced by the same image of Figure of 5a (published manuscript), since they are both controls.

LucianaRomão等人的以下论文“谷氨酸通过TGF-β1途径激活培养的星形胶质细胞的GFAP基因启动子”。（https://onlinelibrary.wiley.com/doi/full/10.1111/j.1471-495.2008.05428.x）已通过作者与《神经化学杂志》编辑部之间的协议予以更正。

已将已更正文件的图2和图5中的重复和不一致之处通知编辑处，如下图所示：

该论文于2007年11月首次提交，随后根据审稿人的要求对数字进行了修订。该手稿随后于2008年出版。编辑部联系了通讯作者FláviaGomes，并收到以下解释：

在第一轮修订中，一位审稿人建议将提交的手稿的图4和图5合并在一起（已发布版本中的图5）。出版的手稿的图5b和5f是正确的。它们与之前提交的图5G和5I（首次提交）完全相同。但是，带有α-TGF-β1的泳道已被删除（请参见下面的红色正方形）。

图2已被修改，第一个提交版本的图5的一部分已不适当地合并到图2中（车道α-TGF）。发表的手稿的图2的四幅图像是错误的（下图中的红色X）。在准备修改后的版本时，第一作者未提供已经作为第一版提交图5的一部分提供给期刊的正确图像。必须用首次提交的图5的α-TGF-β1泳道替换已发布的图2（b，e，h）中的α-TGF-β1泳道（请参见下图中的黄色，紫色和绿色方块）。请注意原始图5（对照/谷氨酸/TGF-β1）和已发布的图2（对照/TGF-β1/ Glu 100μM）之间的列顺序不同。最初发布的图2a和2c错误地显示了相同的情况（MCPG）。图2a将由图5a代替，图5a显示了正确的控制条件。不幸的是，准备第二份稿件时是一个错误。在咨询了该论文的第一作者后，她建议通过接收不同条件（对照和MCPG）的名称，对同一玻璃盖玻片/孔中的田地进行拍照和命名错误。

注意第一行面板；a，d和g（Control /TGF-β1/ Glu 100μM）处于相同的条件（但图像不同），分别与已发表论文的图5（Control / Glutamate /TGF-β1）相同。值得观察的是，这两种情况之间的β-gal阳性细胞数量没有差异（图形）。此外，在检测到β-半乳糖苷酶活性后，直接在显微镜下（现场，而不是成像后）进行了定量（如材料和方法中所述）；和图像已用于提供视觉/代表性插图）。定量图形与第一次提交的版本中提供的图形相同。尽管这个事实并没有使我们犯错的严重性降到最低，但我们想保证它不会影响本文的主要结论。

实例再次归纳在作者提供的下表中：

因此，由于图2a被图5a的同一图像（已出版的手稿）所替代，因为它们都是控件，因此对其进行了纠正。