Cholesterol homeostasis is crucial for brain functioning. Unhealthy nutrition can influence cerebral physiology, but the effect of western diets on brain cholesterol homeostasis, particularly at middle age, is unknown. Given the link between brain cholesterol alteration and beta amyloid production, the aim is to evaluate whether a diet rich in fat and fructose affects the protein network implicated in cholesterol synthesis and shuttling between glial cells and neurons, as well as crucial markers of beta amyloid metabolism.

中文翻译：

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短期西方饮食会损害中年大鼠大脑中的胆固醇稳态和 ​​β 淀粉样蛋白代谢的关键参与者。

胆固醇稳态对大脑功能至关重要。不健康的营养会影响大脑生理机能，但西方饮食对大脑胆固醇稳态的影响，尤其是在中年时，尚不清楚。鉴于大脑胆固醇改变与 β 淀粉样蛋白产生之间的联系，目的是评估富含脂肪和果糖的饮食是否影响与胆固醇合成和神经胶质细胞与神经元之间穿梭相关的蛋白质网络，以及 β 淀粉样蛋白代谢的关键标志物.