Microbial Products and Metabolites Contributing to Alcohol‐Related Liver Disease,Molecular Nutrition & Food Research

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Microbial Products and Metabolites Contributing to Alcohol‐Related Liver Disease
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2020-06-24 , DOI: 10.1002/mnfr.202000023
Bei Gao ₁ , Atoosa Emami ₁ , Shilpa Nath ₁ , Bernd Schnabl _{1,

2}

Affiliation

As a serious public health concern, alcohol‐related liver disease is associated with dysregulations in the intestinal barrier function and the gut microbiota. The liver and gut communicate via the gut–liver axis, through which microbial products and metabolites translocate to the liver. Here, the current knowledge of various microbial products and metabolites which contribute to the alcohol‐related liver diseases, including bile acids, indole‐3‐acetic acid, butyrate, long‐chain fatty acids, endotoxin, cytolysin, β‐glucan, and candidalysin is reviewed. Some of these might serve as therapeutic targets for alcohol‐related liver disease.

中文翻译：

导致酒精相关性肝病的微生物产品和代谢物

作为一个严重的公共卫生问题，酒精相关性肝病与肠道屏障功能和肠道微生物群的失调有关。肝脏和肠道通过肠-肝轴进行交流，微生物产物和代谢物通过该轴转运到肝脏。在这里，目前对导致酒精相关肝病的各种微生物产物和代谢物的了解，包括胆汁酸、吲哚-3-乙酸、丁酸、长链脂肪酸、内毒素、溶细胞素、β-葡聚糖和念珠菌溶血素被审查。其中一些可能作为酒精相关肝病的治疗靶点。

更新日期：2020-06-24

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