Cellular Interactions of Liposomes and PISA Nanoparticles during Human Blood Flow in a Microvascular Network.,Small

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Cellular Interactions of Liposomes and PISA Nanoparticles during Human Blood Flow in a Microvascular Network.
Small ( IF 13.0 ) Pub Date : 2020-06-25 , DOI: 10.1002/smll.202002861
Mai N Vu _{1,

2,

3,

4} , Hannah G Kelly _{1,

3} , Adam K Wheatley _{1,

3} , Scott Peng _{1,

2} , Emily H Pilkington _{1,

2,

3} , Nicholas A Veldhuis _{1,

2} , Thomas P Davis _{1,

2,

5} , Stephen J Kent _{1,

3,

6} , Nghia P Truong _{1,

2}

Affiliation

A key concept in nanomedicine is encapsulating therapeutic or diagnostic agents inside nanoparticles to prolong blood circulation time and to enhance interactions with targeted cells. During circulation and depending on the selected application (e.g., cancer drug delivery or immune modulators), nanoparticles are required to possess low or high interactions with cells in human blood and blood vessels to minimize side effects or maximize delivery efficiency. However, analysis of cellular interactions in blood vessels is challenging and is not yet realized due to the diverse components of human blood and hemodynamic flow in blood vessels. Here, the first comprehensive method to analyze cellular interactions of both synthetic and commercially available nanoparticles under human blood flow conditions in a microvascular network is developed. Importantly, this method allows to unravel the complex interplay of size, charge, and type of nanoparticles on their cellular associations under the dynamic flow of human blood. This method offers a unique platform to study complex interactions of any type of nanoparticles in human blood flow conditions and serves as a useful guideline for the rational design of liposomes and polymer nanoparticles for diverse applications in nanomedicine.

中文翻译：

微血管网络中人体血流过程中脂质体和 PISA 纳米颗粒的细胞相互作用。

纳米医学的一个关键概念是将治疗或诊断剂封装在纳米粒子内，以延长血液循环时间并增强与目标细胞的相互作用。在循环过程中，根据所选的应用（例如，癌症药物输送或免疫调节剂），纳米颗粒需要与人体血液和血管中的细胞具有低或高的相互作用，以最大限度地减少副作用或最大限度地提高输送效率。然而，由于人体血液的成分和血管中的血流动力学流动不同，对血管中细胞相互作用的分析具有挑战性，并且尚未实现。在这里，开发了第一个综合方法来分析微血管网络中人体血流条件下合成和市售纳米粒子的细胞相互作用。重要的是，这种方法可以揭示纳米粒子的尺寸、电荷和类型在人体血液动态流动下其细胞关联的复杂相互作用。该方法提供了一个独特的平台来研究人体血流条件下任何类型纳米颗粒的复杂相互作用，并为合理设计脂质体和聚合物纳米颗粒在纳米医学中的各种应用提供了有用的指导。

更新日期：2020-08-20

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