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Diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy in clinical practice: A survey among Dutch neurologists.
Journal of the Peripheral Nervous System ( IF 3.9 ) Pub Date : 2020-07-09 , DOI: 10.1111/jns.12399
Merel C Broers 1 , Pieter A van Doorn 1 , Krista Kuitwaard 2 , Filip Eftimov 3 , Paul W Wirtz 4 , Stephan Goedee 5 , Hester F Lingsma 6 , Bart C Jacobs 1, 7
Affiliation  

The diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is often a challenge. The clinical presentation is diverse, accurate biomarkers are lacking, and the best strategy to initiate and maintain treatment is unclear. The aim of this study was to determine how neurologists diagnose and treat CIDP. We conducted a cross‐sectional survey on diagnostic and treatment practices among Dutch neurologists involved in the clinical care of CIDP patients. Forty‐four neurologists completed the survey (44/71; 62%). The respondents indicated to use the European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) 2010 CIDP guideline for the diagnosis in 77% and for treatment in 50%. Only 57% of respondents indicated that the presence of demyelinating electrophysiological findings was mandatory to confirm the diagnosis of CIDP. Most neurologists used intravenous immunoglobulins (IVIg) as first choice treatment, but the indications to start, optimize, or withdraw IVIg, and the use of other immune‐modulatory therapies varied. University‐affiliated respondents used the EFNS/PNS 2010 diagnostic criteria, nerve imaging tools, and immunosuppressive drugs more often. Despite the existence of an international guideline, there is considerable variation among neurologists in the strategies employed to diagnose and treat CIDP. More specific recommendations regarding: (a) the minimal set of electrophysiological requirements to diagnose CIDP, (b) the possible added value of nerve imaging, especially in patients not meeting the electrodiagnostic criteria, (c) the most relevant serological examinations, and (d) the clear treatment advice, in the new EFNS/PNS guideline, would likely support its implementation in clinical practice.

中文翻译:

临床实践中慢性炎性脱髓鞘性多发性神经根神经病的诊断和治疗:荷兰神经病学家的调查。

慢性炎症性脱髓鞘性多发性神经根神经病 (CIDP) 的诊断和治疗通常是一个挑战。临床表现多样,缺乏准确的生物标志物,启动和维持治疗的最佳策略尚不清楚。本研究的目的是确定神经科医生如何诊断和治疗 CIDP。我们对参与 CIDP 患者临床护理的荷兰神经科医生进行了一项关于诊断和治疗实践的横断面调查。44 名神经科医生完成了调查(44/71;62%)。受访者表示使用欧洲神经学会联合会/外周神经学会 (EFNS/PNS) 2010 CIDP 指南进行诊断,其中 77% 用于诊断,50% 用于治疗。只有 57% 的受访者表示脱髓鞘电生理结果的存在是确认 CIDP 诊断所必需的。大多数神经科医生使用静脉注射免疫球蛋白 (IVIg) 作为首选治疗方法,但启动、优化或停用 IVIg 的适应症以及其他免疫调节疗法的使用各不相同。大学附属受访者更频繁地使用 EFNS/PNS 2010 诊断标准、神经成像工具和免疫抑制药物。尽管存在国际指南,但神经科医生在诊断和治疗 CIDP 的策略方面存在相当大的差异。更具体的建议涉及:(a) 诊断 CIDP 的最低电生理要求,(b) 神经成像的可能附加值,
更新日期:2020-07-09
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