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MnO2 Nanoclusters Decorated on GrapheneModified Pencil Graphite Electrode for Non‐Enzymatic Determination of Cholesterol
Electroanalysis ( IF 2.7 ) Pub Date : 2020-06-24 , DOI: 10.1002/elan.202000049 Sherin Rison 1, 2 , K. B. Akshaya 2 , Vinay S Bhat 3 , G. Shanker 4 , T. Maiyalagan 5 , E. K. Joice 1 , Gurumurthy Hegde 3 , Anitha Varghese 2
Electroanalysis ( IF 2.7 ) Pub Date : 2020-06-24 , DOI: 10.1002/elan.202000049 Sherin Rison 1, 2 , K. B. Akshaya 2 , Vinay S Bhat 3 , G. Shanker 4 , T. Maiyalagan 5 , E. K. Joice 1 , Gurumurthy Hegde 3 , Anitha Varghese 2
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Electrochemically deposited MnO2 on graphene coated Pencil Graphite Electrode (PGE) has been used to develop a facile electrochemical sensor for the determination of Cholesterol. Cyclic voltammetric (CV) studies and electrochemical impedance spectroscopic (EIS) technique were used to investigate the electrochemical properties of the modified sensing platform. The physicochemical properties of the modified electrodes were characterized by X‐ray photoelectron spectroscopy (XPS), Scanning electron microscopy (SEM), Transmission electron microscopy (TEM), X‐ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). The experimental conditions such as effect of scan rate, concentration and pH were optimized. The linear dynamic range for the determination of Cholesterol was found to be 12×10−10 M–240×10−10 M under optimum conditions. The ultralow level of detection limit (0.42 nM) demonstrates the high sensitivity of the proposed method. The developed method was successfully applied for the non‐enzymatic determination of Cholesterol in human blood samples at ultralow levels.
中文翻译：
石墨烯修饰的石墨电极上修饰的MnO2纳米簇用于非酶法测定胆固醇
在涂有石墨烯的铅笔状石墨电极（PGE）上电化学沉积的MnO 2已用于开发一种用于测定胆固醇的简便电化学传感器。循环伏安（CV）研究和电化学阻抗谱（EIS）技术用于研究改进的传感平台的电化学性能。通过X射线光电子能谱（XPS），扫描电子显微镜（SEM），透射电子显微镜（TEM），X射线衍射（XRD）和傅里叶变换红外光谱（FTIR）对改性电极的理化性质进行了表征。优化了扫描速率，浓度和pH等实验条件。测定胆固醇的线性动态范围为12×10 最佳条件下为−10 M–240×10 -10M。超低检测限（0.42 nM）证明了该方法的高灵敏度。所开发的方法已成功地用于非酶法超低水平测定人血中的胆固醇。
更新日期：2020-06-24
中文翻译：
石墨烯修饰的石墨电极上修饰的MnO2纳米簇用于非酶法测定胆固醇
在涂有石墨烯的铅笔状石墨电极（PGE）上电化学沉积的MnO 2已用于开发一种用于测定胆固醇的简便电化学传感器。循环伏安（CV）研究和电化学阻抗谱（EIS）技术用于研究改进的传感平台的电化学性能。通过X射线光电子能谱（XPS），扫描电子显微镜（SEM），透射电子显微镜（TEM），X射线衍射（XRD）和傅里叶变换红外光谱（FTIR）对改性电极的理化性质进行了表征。优化了扫描速率，浓度和pH等实验条件。测定胆固醇的线性动态范围为12×10 最佳条件下为−10 M–240×10 -10M。超低检测限（0.42 nM）证明了该方法的高灵敏度。所开发的方法已成功地用于非酶法超低水平测定人血中的胆固醇。
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