Depression is a common mental illness and a leading cause of disability worldwide. Despite various treatment modalities including pharmacotherapy and psychotherapy, a sizeable portion of patients fail to recover from their depressive episodes, and are diagnosed with treatment‐resistant depression (TRD). Neurosurgical methods involving lesioning or stimulating specific brain structures are a possible option for TRD

中文翻译：

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双边热囊切开术结合磁共振引导聚焦超声对难治性抑郁症患者的概念验证研究。

抑郁症是一种常见的精神疾病，也是全球范围内致残的主要原因。尽管包括药物治疗和心理治疗在内的治疗方法多种多样，但仍有相当一部分患者无法从抑郁发作中恢复过来，并被诊断出患有抗药性抑郁症（TRD）。涉及损伤或刺激特定脑部结构的神经外科方法可能是TRD的一种选择