Achieving Microparticles with Cell‐Instructive Surface Chemistry by Using Tunable Co‐Polymer Surfactants,Advanced Functional Materials

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Achieving Microparticles with Cell‐Instructive Surface Chemistry by Using Tunable Co‐Polymer Surfactants
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2020-06-25 , DOI: 10.1002/adfm.202001821
Adam A. Dundas _{1,

2} , Valentina Cuzzucoli Crucitti ₁ , Simon Haas ₁ , Jean‐Frédéric Dubern ₃ , Arsalan Latif ₄ , Manuel Romero ₃ , Olutoba Sanni ₂ , Amir M. Ghaemmaghami ₄ , Paul Williams ₃ , Morgan R. Alexander ₂ , Ricky Wildman ₁ , Derek J. Irvine ₁

Affiliation

A flow‐focusing microfluidic device is used to produce functionalized monodisperse polymer particles with surface chemistries designed to control bacterial biofilm formation. This is achieved by using molecularly designed bespoke surfactants synthesized via catalytic chain transfer polymerization. This novel approach of using polymeric surfactants, often called surfmers, containing a biofunctional moiety contrasts with the more commonly employed emulsion methods. Typically, the surface chemistry of microparticles are dominated by unwanted surfactants that dilute/mask the desired surface response. Time of flight secondary ion mass spectrometry (ToF‐SIMS) analysis of particles demonstrates that the comb‐graft surfactant is located on the particle surface. Biofilm experiments show how specifically engineered surface chemistries, generated by the surfactants, successfully modulate bacterial attachment to both polymer films, and microparticles. Thus, this paper outlines how the use of designed polymeric surfactants and droplet microfluidics can exert control over both the surface chemistry and size distribution of microparticle materials, demonstrating their critical importance for controlling surface‐cell response.

中文翻译：

通过使用可调节的共聚合物表面活性剂，通过具有细胞指导性表面化学作用的微粒

集中流动的微流控设备用于生产功能化的单分散聚合物颗粒，其表面化学物质旨在控制细菌生物膜的形成。这是通过使用分子设计定制的表面活性剂来实现的，该表面活性剂是通过催化链转移聚合合成的。使用包含生物功能部分的通常被称为表面活性剂的聚合物表面活性剂的这种新颖方法与更常用的乳液方法形成对比。通常，微粒的表面化学以不需要的表面活性剂为主，这些表面活性剂稀释/掩盖了所需的表面响应。飞行时间二次离子质谱（ToF‐SIMS）分析表明，梳状接枝表面活性剂位于颗粒表面。生物膜实验表明如何对表面化学进行专门设计，表面活性剂产生的污染物成功地调节细菌附着在聚合物薄膜和微粒上。因此，本文概述了如何使用设计的聚合物表面活性剂和液滴微流体来控制微粒材料的表面化学和尺寸分布，从而证明它们对于控制表面细胞响应至关重要。

更新日期：2020-09-03

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