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Supercritical fluid technologies applied to the extraction of compounds of industrial interest from Cannabis sativa L. and to their pharmaceutical formulations: A review
The Journal of Supercritical Fluids ( IF 3.4 ) Pub Date : 2020-06-25 , DOI: 10.1016/j.supflu.2020.104960
Lucia Baldino , Mariarosa Scognamiglio , Ernesto Reverchon

In this work is proposed a critical review of the scientific literature about the extraction of products of industrial interest from Cannabis sativa L., like cannabinoids, essential oil and seed oil, using supercritical and subcritical CO2. Traditional techniques are also reviewed and critically discussed to evidence the advantages of CO2 processing. The extracts can be also used in pharmaceutical and biomedical formulations, in form of co-precipitates and capsules, to improve active compounds bioavailability and performance. Further studies can be required, mainly based on the analysis of mass transfer resistances during extraction and on solubility data of the compounds to be extracted, to improve process selectivity and the purity of the extracts obtained.



中文翻译:

超临界流体技术用于从大麻中提取工业上感兴趣的化合物及其药物制剂:综述

在这项工作中,提出了对使用超临界和亚临界CO 2大麻植物中提取具有工业价值的产品(如大麻素,精油和种子油)的科学文献的综述。还回顾并严格讨论了传统技术,以证明CO 2处理的优势。提取物还可以共沉淀物和胶囊的形式用于药物和生物医学制剂中,以改善活性化合物的生物利用度和性能。可能需要进一步的研究,主要是基于对萃取过程中传质阻力的分析以及所萃取化合物的溶解度数据,以提高工艺选择性和所得萃取物的纯度。

更新日期:2020-06-25
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