Background and aim

The effect of anticoagulation control on overall Health-Related Quality of Life (HRQoL) in patients taking warfarin in Malaysia has not been explored yet. Therefore, this study aimed to evaluate HRQoL among patients on warfarin in Malaysia.

Methods

HRQoL among patients on warfarin was measured using WHOQOL-BREF (World Health Organization Quality of life Assessment: Brief Version). Descriptive and inferential statistical analysis was done using Statistical Package for the Social Sciences (SPSS) version 22.

Results

Out of 319 patients, more female patients were observed than the males (n = 221, 69.3%, and n = 98, 30.7% respectively). Mean scores for the physical (61.14 ± 15.96), psychological (68.58 ± 16.11), social (63.55 ± 27.06) and environmental domains (62.78 ± 17.58) were observed. Statistically, a significant association was found between the comorbidities other than CVDs with health satisfaction (p = 0.002), physical (p = 0.001), psychological (p < 0.001), social (p = 0.003) and environmental domains of the WHOQOL-BREF. A weak positive correlation between overall health satisfaction and the social domain (r = 0.153) and a moderate positive correlation between the physical and environmental domains (r = 0.628) of the WHOQOL-BREF were observed.

Conclusion

Patients had overall better perceived HRQoL scores in the psychological domain as compared with the rest of the domains of the WHOQOL-BREF. Age, gender, employment status, education level, the indication of use and duration of warfarin therapy associated with overall perceived HRQoL.

中文翻译：

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使用 WHOQOL-BREF 评估生活质量：马来西亚华法林患者的横断面见解。

背景和目的

尚未探索抗凝控制对马来西亚华法林患者整体健康相关生活质量 (HRQoL) 的影响。因此，本研究旨在评估马来西亚华法林患者的 HRQoL。

方法

使用 WHOQOL-BREF（世界卫生组织生活质量评估：简要版）测量华法林患者的 HRQoL。使用社会科学统计软件包 (SPSS) 第 22 版进行描述性和推论性统计分析。

结果

在 319 名患者中，观察到的女性患者多于男性（分别为 n = 221, 69.3% 和 n = 98, 30.7%）。观察到身体 (61.14 ± 15.96)、心理 (68.58 ± 16.11)、社会 (63.55 ± 27.06) 和环境领域 (62.78 ± 17.58) 的平均得分。统计上，发现除了 CVD 以外的合并症与 WHOQOL-BREF 的健康满意度 ( p  = 0.002)、身体 ( p = 0.001 )、心理 ( p < 0.001 )、社会 ( p = 0.003 ) 和环境领域之间存在显着关联. 整体健康满意度与社会领域之间呈弱正相关（r = 0.153），而身体和环境领域之间呈中度正相关（r = 0.628 ) WHOQOL-BREF 被观察到。

结论

与 WHOQOL-BREF 的其他领域相比，患者在心理领域的 HRQoL 评分总体上更好。与总体感知 HRQoL 相关的年龄、性别、就业状况、教育水平、华法林治疗的使用指征和持续时间。