Association between duration of breastfeeding based on maternal reports and dorsal and ventral striatum and medial orbital gyrus volumes in early adolescence,NeuroImage

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Association between duration of breastfeeding based on maternal reports and dorsal and ventral striatum and medial orbital gyrus volumes in early adolescence
NeuroImage ( IF 4.7 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.neuroimage.2020.117083
Daisuke Koshiyama ₁ , Naohiro Okada ₂ , Shuntaro Ando ₃ , Shinsuke Koike ₄ , Noriaki Yahata ₅ , Kentaro Morita ₁ , Kingo Sawada ₆ , Susumu Morita ₁ , Shintaro Kawakami ₁ , Sho Kanata ₇ , Shinya Fujikawa ₁ , Noriko Sugimoto ₁ , Rie Toriyama ₁ , Mio Masaoka ₁ , Tsuyoshi Araki ₁ , Yukiko Kano ₈ , Kaori Endo ₉ , Syudo Yamasaki ₉ , Atsushi Nishida ₉ , Mariko Hiraiwa-Hasegawa ₁₀ , Kiyoto Kasai ₂

Affiliation

Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan; The International Research Center for Neurointelligence (WPI-IRCN), University of Tokyo Institutes for Advanced Study (UTIAS), The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan; Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan.
Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan; The International Research Center for Neurointelligence (WPI-IRCN), University of Tokyo Institutes for Advanced Study (UTIAS), The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan; University of Tokyo Institute for Diversity & Adaptation of Human Mind (UTIDAHM), 3-8-1, Komaba, Meguro-ku, Tokyo, 153-8902, Japan; Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, The University of Tokyo, 3-8-1, Komaba, Meguro-ku, Tokyo, 153-8902, Japan.
Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan; Institute for Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan; Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan.
Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan; Office for Mental Health Support, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan; Department of Psychiatry, Teikyo University School of Medicine 2-11-1 Kaga Itabashi-ku, Tokyo, 173-8605, Japan.
Department of Child Psychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan.
Department of Evolutionary Studies of Biosystems, School of Advanced Sciences, The Graduate University for Advanced Studies (SOKENDAI), Shonan Village, Hayama, Kanagawa, 240-0193, Japan.

Maternal breastfeeding has an impact on motor and emotional development in children of the next generation. Elucidating how breastfeeding during infancy affects brain regional structural development in early adolescence will be helpful for promoting healthy development. However, previous studies that have shown relationships between breastfeeding during infancy and cortical brain regions in adolescence are usually based on maternal retrospective recall of breastfeeding, and the accuracy of the data is unclear. In this study, we investigated the association between breastfeeding duration and brain regional volume in a population-neuroimaging study of early adolescents in Japan (N = 207; 10.5-13.4 years) using voxel-based morphometry, which enabled us to analyze the whole brain. We evaluated breastfeeding duration as indexed by maternal and child health handbook records during infancy. The results showed a significant positive correlation between the duration of breastfeeding and gray matter volume in the dorsal and ventral striatum and the medial orbital gyrus. Post hoc exploratory analyses revealed that the duration of breastfeeding was significantly correlated with emotional behavior. Additionally, the volume in the medial orbital gyrus mediated an association between breastfeeding duration and emotional behavior. This is the first study to evaluate the effect of breastfeeding during infancy on regional brain volumes in early adolescence based on maternal and child health handbook records. Our findings shed light upon the importance of maternal breastfeeding for brain development related to emotional and motivational processing in early adolescence.

中文翻译：

基于母亲报告的母乳喂养持续时间与青春期早期背侧和腹侧纹状体和内侧眶回体积之间的关联

母亲母乳喂养对下一代儿童的运动和情感发展有影响。阐明婴儿期母乳喂养对青春期早期大脑区域结构发育的影响，将有助于促进健康发育。然而，之前的研究表明婴儿期母乳喂养与青春期大脑皮质区域之间的关系通常是基于母亲对母乳喂养的回顾性回忆，数据的准确性尚不清楚。在这项研究中，我们使用基于体素的形态测量法对日本早期青少年（N = 207；10.5-13.4 岁）的人口神经影像学研究中的母乳喂养持续时间与大脑区域体积之间的关联进行了分析，这使我们能够分析整个大脑. 我们评估了婴儿期母婴健康手册记录索引的母乳喂养持续时间。结果表明，母乳喂养的持续时间与背侧和腹侧纹状体以及眶内侧回的灰质体积呈显着正相关。事后探索性分析显示，母乳喂养的持续时间与情绪行为显着相关。此外，眶内侧回的体积介导了母乳喂养持续时间和情绪行为之间的关联。这是第一项根据母婴健康手册记录评估婴儿期母乳喂养对青春期早期区域脑容量影响的研究。

更新日期：2020-10-01

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