Obesity patients are more susceptible to develop COVID-19 severe outcome due to the role of angiotensin-converting enzyme 2 (ACE2) in the viral infection. ACE2 is regulated in the human cells by different genes associated with increased (TLR3, HAT1, HDAC2, KDM5B, SIRT1, RAB1A, FURIN and ADAM10) or decreased (TRIB3) virus replication. RNA-seq data revealed 14857 genes expressed in human subcutaneous adipocytes, including genes mentioned above. Irisin treatment increased by 3-fold the levels of TRIB3 transcript and decreased the levels of other genes. The decrease in FURIN and ADAM10 expression enriched diverse biological processes, including extracellular structure organization. Our results, in human subcutaneous adipocytes cell culture, indicate a positive effect of irisin on the expression of multiple genes related to viral infection by SARS-CoV-2; furthermore, translatable for other tissues and organs targeted by the novel coronavirus and present, thus, promising approaches for the treatment of COVID-19 infection as therapeutic strategy to decrease ACE2 regulatory genes.

由于血管紧张素转换酶 2 ( ACE2 ) 在病毒感染中的作用，肥胖患者更容易出现 COVID-19 严重后果。 ACE2在人类细胞中受到与病毒复制增加（ TLR3 、 HAT1 、 HDAC2 、 KDM5B 、 SIRT1 、 RAB1A 、 FURIN和ADAM10 ）或减少（ TRIB3 ）相关的不同基因的调节。 RNA-seq数据揭示了人皮下脂肪细胞中表达的14857个基因，包括上述基因。鸢尾素处理使TRIB3转录物水平增加了 3 倍，并降低了其他基因的水平。 FURIN和ADAM10表达的减少丰富了多种生物过程，包括细胞外结构组织。我们在人皮下脂肪细胞培养中的结果表明，鸢尾素对与 SARS-CoV-2 病毒感染相关的多个基因的表达具有积极作用；此外，可转化为新型冠状病毒针对的其他组织和器官，因此，作为减少ACE2调节基因的治疗策略，提出了治疗 COVID-19 感染的有前途的方法。