Growth hormone (GH) is pituitary derived hormone which acts on most tissues of the body either directly or indirectly and affects many metabolic processes throughout life. Genetically engineered mouse lines have become vital tools for uncovering the various in vivo activities of a GH. A particularly useful mouse line has been the GH receptor (GHR) gene disrupted or knockout (KO) mouse which has been used world-wide in many studies. Recent advances in biotechnology have allowed the development of tissue-specific knockout mouse lines which allows for more direct enquiries on the activities of a given protein in specific tissues or cell types. Accordingly, twenty-two novel tissue-specific GHRKO mouse lines have been developed in the last eleven years. In this paper we provide a detailed list and review the phenotypic changes that occur in each of these tissue-specific GHRKO mouse lines.

生长激素（GH）是脑垂体衍生的激素，它直接或间接作用于人体的大多数组织，并在一生中影响许多代谢过程。基因工程小鼠系已成为揭示体内各种生物的重要工具GH的活动。尤其有用的小鼠系是GH受体（GHR）基因破坏或敲除（KO）小鼠，已在全球范围内用于许多研究中。生物技术的最新进展已允许开发组织特异性基因敲除小鼠系，从而可以更直接地查询特定蛋白质在特定组织或细胞类型中的活性。因此，在最近的十一年中，已经开发了二十二种新颖的组织特异性GHRKO小鼠品系。在本文中，我们提供了详细的列表，并回顾了在这些组织特异性GHRKO小鼠系中每种发生的表型变化。