Coronavirus disease-19 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is now a pandemic threat. This virus is supposed to be spread by human to human transmission. Cellular angiotensin-converting enzyme 2 (ACE2) is the receptor of SARS-CoV-2 which is identical or similar in different species of animals such as pigs, ferrets, cats, orangutans, monkeys, and humans. Moreover, a recent study predicted that dogs might be secondary hosts during the evolution of SARS-CoV-2 from bat to human. Therefore, there is a possibility of spreading SARS-CoV-2 through domestic pets. There are now many reports of SARS-CoV-2 positive cases in dogs, cats, tigers, lion, and minks. Experimental data showed ferrets and cats are highly susceptible to SARS-CoV-2 as infected by virus inoculation and can transmit the virus directly or indirectly by droplets or airborne routes. Based on these natural infection reports and experimental data, whether the pets are responsible for SARS-CoV-2 spread to humans; needs to be deeply investigated. Humans showing clinical symptoms of respiratory infections have been undergoing for the COVID-19 diagnostic test but many infected people and few pets confirmed with SARS-CoV-2 remained asymptomatic. In this review, we summarize the natural cases of SARS-CoV-2 in animals with the latest researches conducted in this field. This review will be helpful to think insights of SARS-CoV-2 transmissions, spread, and demand for seroprevalence studies, especially in companion animals.

由严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 引起的冠状病毒病 19 (COVID-19) 目前已成为一种大流行威胁。这种病毒应该是通过人际传播传播的。细胞血管紧张素转换酶 2 (ACE2) 是 SARS-CoV-2 的受体，在猪、雪貂、猫、猩猩、猴子和人类等不同物种的动物中是相同或相似的。此外，最近的一项研究预测，在 SARS-CoV-2 从蝙蝠到人类的进化过程中，狗可能是第二宿主。因此，SARS-CoV-2有可能通过家养宠物传播。目前有许多狗、猫、老虎、狮子和水貂身上出现 SARS-CoV-2 阳性病例的报告。实验数据显示，雪貂和猫通过病毒接种感染，对SARS-CoV-2高度敏感，可以通过飞沫或空气传播途径直接或间接传播病毒。根据这些自然感染报告和实验数据，宠物是否是 SARS-CoV-2 传播给人类的罪魁祸首；需要深入调查。表现出呼吸道感染临床症状的人类一直在接受 COVID-19 诊断测试，但许多感染者和少数被确诊患有 SARS-CoV-2 的宠物仍然无症状。在这篇综述中，我们总结了动物中 SARS-CoV-2 的自然病例以及该领域的最新研究。这篇综述将有助于深入了解 SARS-CoV-2 的传播、传播和血清阳性率研究的需求，特别是在伴侣动物中。