当前位置: X-MOL 学术J. Inorg. Biochem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Synthesis, characterization, photoluminescence, antiproliferative activity, and DNA interaction of cadmium(II) substituted 4'-phenyl-terpyridine compounds.
Journal of Inorganic Biochemistry ( IF 3.8 ) Pub Date : 2020-06-25 , DOI: 10.1016/j.jinorgbio.2020.111165
Jiahe Li 1 , Rongping Liu 2 , Jinzhang Jiang 2 , Xing Liang 2 , Gang Huang 3 , Dengfeng Yang 4 , Hailan Chen 5 , Lixia Pan 3 , Zhen Ma 6
Affiliation  

A series of CdCl2 complexes (1a1f and 2a2c) with 4′-(substituted-phenyl)-2,2′:6′,2″-terpyridine compounds bearing hydrogen (L1a), p-methyl (L1b), p-phenyl (L1c), p-tolyl (L1d), p-carboxyl (L1e), p-fluoro (L1f), p-hydroxyl (L2a), m-hydroxyl (L2b) or o-hydroxyl (L2c), were prepared and characterized by 1H NMR, IR, elemental analysis and single crystal X-ray diffraction. All the compounds display interesting photoluminescent properties and different maximal emission peaks due to the difference of the substituent groups. The in vitro antiproliferative activities against four human carcinoma cell lines, A549, Bel-7402, Eca-109 and MCF-7, were investigated and cell viability studies indicate that the compounds have excellent results with the lowest IC50 values of 0.372 (1c), 1.003 (1c), 1.161 (1b) and 0.231 (1c) μM, respectively. The DNA interaction was studied by fluorescence titration, circular dichroism spectroscopy and molecular modeling methods. Spectrophotometric results reveal that the compounds have strong affinity binding with DNA as intercalators and molecular docking studies indicate that the binding is contributed by the π…π stacking and hydrogen bonds.



中文翻译:

镉(II)取代的4'-苯基-联吡啶化合物的合成,表征,光致发光,抗增殖活性和DNA相互作用。

一系列具有4'-(取代的苯基)-2,2':6',2''-叔吡啶化合物的CdCl 2配合物(1a - 1f2a - 2c),带有氢(L 1a),甲基(L图1b),p -苯基(大号1C),p -甲苯基(大号1D),p -羧基(大号1E),p -氟(大号1F),p -羟基(大号2A),-羟基(大号制备了2b)或羟基( L 2c),并通过1 H NMR,IR,元素分析和单晶X射线衍射进行了表征。由于取代基的不同,所有化合物均表现出令人感兴趣的光致发光特性和不同的最大发射峰。研究针对四种人类癌细胞系A549,Bel-7402,Eca-109和MCF-7的体外抗增殖活性,并且细胞活力研究表明这些化合物具有优异的结果,最低IC 50值为0.372( 1c) ,1.003( 1c),1.161( 1b)和0.231( 1c)μM。通过荧光滴定,圆二色光谱和分子建模方法研究了DNA的相互作用。分光光度法的结果表明,该化合物与DNA具有很强的亲和力,可作为嵌入剂,分子对接研究表明该结合是由π…π堆积和氢键所致。

更新日期:2020-07-08
down
wechat
bug