A series of CdCl₂ complexes (1a–1f and 2a–2c) with 4′-(substituted-phenyl)-2,2′:6′,2″-terpyridine compounds bearing hydrogen (L^1a), p-methyl (L^1b), p-phenyl (L^1c), p-tolyl (L^1d), p-carboxyl (L^1e), p-fluoro (L^1f), p-hydroxyl (L^2a), m-hydroxyl (L^2b) or o-hydroxyl (L^2c), were prepared and characterized by ¹H NMR, IR, elemental analysis and single crystal X-ray diffraction. All the compounds display interesting photoluminescent properties and different maximal emission peaks due to the difference of the substituent groups. The in vitro antiproliferative activities against four human carcinoma cell lines, A549, Bel-7402, Eca-109 and MCF-7, were investigated and cell viability studies indicate that the compounds have excellent results with the lowest IC₅₀ values of 0.372 (1c), 1.003 (1c), 1.161 (1b) and 0.231 (1c) μM, respectively. The DNA interaction was studied by fluorescence titration, circular dichroism spectroscopy and molecular modeling methods. Spectrophotometric results reveal that the compounds have strong affinity binding with DNA as intercalators and molecular docking studies indicate that the binding is contributed by the π…π stacking and hydrogen bonds.

一系列具有4'-（取代的苯基）-2,2'：6'，2''-叔吡啶化合物的CdCl ₂配合物（1a - 1f和2a - 2c），带有氢（L ^1a），对甲基（L^图1b），p -苯基（大号^1C），p -甲苯基（大号^1D），p -羧基（大号^1E），p -氟（大号^1F），p -羟基（大号^2A），米-羟基（大号制备了^2b）或邻羟基（ L ^2c），并通过¹ H NMR，IR，元素分析和单晶X射线衍射进行了表征。由于取代基的不同，所有化合物均表现出令人感兴趣的光致发光特性和不同的最大发射峰。研究了针对四种人类癌细胞系A549，Bel-7402，Eca-109和MCF-7的体外抗增殖活性，并且细胞活力研究表明这些化合物具有优异的结果，最低IC ₅₀值为0.372（ 1c） ，1.003（ 1c），1.161（ 1b）和0.231（ 1c）μM。通过荧光滴定，圆二色光谱和分子建模方法研究了DNA的相互作用。分光光度法的结果表明，该化合物与DNA具有很强的亲和力，可作为嵌入剂，分子对接研究表明该结合是由π…π堆积和氢键所致。