The unfolded protein response (UPR) is a highly conserved molecular machinery, which protects the cells against a diverse variety of stimuli. Activation of this element has been associated with both human health and disease. The purpose of the current manuscript is to provide the most updated information on the involvement of UPR towards the improvement; or deterioration of cardiovascular functions. Since UPR is consisted of three distinct elements, namely the activating transcription factor 6, the protein kinase RNA-like endoplasmic reticulum kinase; and the inositol-requiring enzyme-1α, a highly orchestrated manipulation of those molecular branches may provide new therapeutic possibilities against the severe outcomes of cardiovascular disease.

未折叠蛋白反应 (UPR) 是一种高度保守的分子机制，可保护细胞免受各种刺激。该元素的激活与人类健康和疾病有关。当前手稿的目的是提供关于普遍定期审议参与改进的最新信息；或心血管功能恶化。由于 UPR 由三个不同的元素组成，即激活转录因子 6、蛋白激酶 RNA 样内质网激酶；和需要肌醇的酶-1α，对这些分子分支的高度协调操作可能为对抗心血管疾病的严重后果提供新的治疗可能性。