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Two Cu(II) coordination polymers: photocatalytic Cr(VI) reduction and treatment activity on influenza A virus infection by inducing IFITM expression
Arabian Journal of Chemistry ( IF 5.3 ) Pub Date : 2020-08-01 , DOI: 10.1016/j.arabjc.2020.06.021
Liang Chen , Jun Chen , Li-Mei Zhu

Abstract Via H4L (5,5′-(1,3,6,8-tetraoxobenzo [lmn] [3], [8] phenanthroline-2–7-diyl) bis-1,3-benzenedicarboxylic acid), the rigid π-conjugated connector reacting with different N-donor auxiliary connectors and Cu(NO3)2·3H2O under the solvothermal conditions, two new coordination polymers (CPs) based on Cu ions as nodes {[Cu(H2L)(4,4′-bibp)(H2O)2]}n (1) and {[Cu(L)0.5(4,4′-bimb)(H2O)2]·3·.5H2O·2DMA}n (2) {4,4′-bimb = 4,4′-bis(imidazol-1-ylmethyl) bipheny and 4,4′-bibp = 4,4′-bis(imidazolyl)biphenyl, DMA = N,N- dimethylacetamide} were prepared and characterized. The photocatalytic reduction of Cr(VI) and dye degradation were performed with these two CPs. The results showed that under the ultraviolet irradiation, they revealed excellent photocatalytic reduction of Cr(VI) in thirty minutes, and the reduction efficiency was over 98%. According to results of the in vitro macrophage infectious model, in comparison with complex 2, complex 1 has stronger treatment activity on influenza A virus infection. Then, the ELISA test exhibited that complex could significantly regulated the releasing the INF-γ, but not complex 2. Next, the results of RT-PCR suggested that complex 1 is much better than complex 2 on reducing the relative expression of the interferon inducible transmembrane proteins (IFITM). Finally, the western blot further confirmed the induced ability of complex 1 on the IFITM in protein level.

中文翻译:

两种 Cu(II) 配位聚合物:光催化 Cr(VI) 还原和通过诱导 IFITM 表达对甲型流感病毒感染的治疗活性

摘要 通过 H4L (5,5'-(1,3,6,8-tetraoxobenzo [lmn] [3], [8] phenanthroline-2–7-diyl) bis-1,3-benzodicarbium),刚性 π -共轭连接器在溶剂热条件下与不同的 N 供体辅助连接器和 Cu(NO3)2·3H2O 反应,两种基于 Cu 离子作为节点的新型配位聚合物 (CP) {[Cu(H2L)(4,4'-bibp) )(H2O)2]}n (1) 和 {[Cu(L)0.5(4,4'-bimb)(H2O)2]·3·.5H2O·2DMA}n (2) {4,4'- bimb = 4,4'-双(咪唑-1-基甲基)联苯和4,4'-bibp = 4,4'-双(咪唑基)联苯,DMA = N,N-二甲基乙酰胺}被制备和表征。用这两种 CP 进行 Cr(VI) 的光催化还原和染料降解。结果表明,在紫外线照射下,他们在三十分钟内表现出优异的Cr(VI)光催化还原,还原效率超过98%。根据体外巨噬细胞感染模型的结果,与复合物2相比,复合物1对甲型流感病毒感染具有更强的治疗活性。然后,ELISA 测试表明复合物可以显着调节 INF-γ 的释放,但不能显着调节复合物 2。 其次,RT-PCR 结果表明复合物 1 比复合物 2 在降低干扰素诱导因子的相对表达方面要好得多。跨膜蛋白 (IFITM)。最后,蛋白质印迹进一步证实了复合物1在蛋白质水平上对IFITM的诱导能力。RT-PCR结果表明,复合物1在降低干扰素诱导跨膜蛋白(IFITM)相对表达量方面明显优于复合物2。最后,蛋白质印迹进一步证实了复合物1在蛋白质水平上对IFITM的诱导能力。RT-PCR结果表明,复合物1在降低干扰素诱导跨膜蛋白(IFITM)相对表达量方面明显优于复合物2。最后,蛋白质印迹进一步证实了复合物1在蛋白质水平上对IFITM的诱导能力。
更新日期:2020-08-01
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