Abstract —The resistance of leukemic cells to the action of chemotherapeutic drugs is the main reason for insufficient efficacy in the treatment of acute myeloid leukemia. Microenvironmental factors play one of the key roles in the formation of the phenotype of drug resistance of leukemic cells. The elucidation of the nature of drug resistance mediated by the conditions of the microenvironment is important for the identification of new pharmacological targets for conservative directed therapy. We conducted a study of the role of differentiation in the macrophage direction in increasing the drug resistance of acute myeloid leukemia cells in multicellular aggregates. It was shown that maturation does not occur in the macrophage direction in multicellular aggregates. These data indicate that other mechanisms contribute to an increased drug resistance of acute myeloid leukemia cells in multicellular aggregates.

中文翻译：

---

多细胞聚集体中急性髓系白血病细胞巨噬细胞分化的研究

摘要——白血病细胞对化疗药物的耐药性是治疗急性髓系白血病疗效不足的主要原因。微环境因素在白血病细胞耐药表型的形成中起关键作用之一。阐明由微环境条件介导的耐药性的性质对于确定用于保守定向治疗的新药理学靶点很重要。我们对巨噬细胞方向的分化在增加多细胞聚集体中急性髓系白血病细胞的耐药性中的作用进行了研究。结果表明，在多细胞聚集体中，成熟不会在巨噬细胞方向发生。